SGDB: A Sports Gene Database for Visualization of Sports Effects on Human Skeletal Muscle Gene Expression

The relationship between physical exercise and human health has been widely recognized by sports-related professionals and the public. However, the molecular mechanism behind sports remains unclear. A microarray sequencing technology has been widely used to detect gene changes after physical exercis...

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Bibliographic Details
Published in:IEEE access 2020, Vol.8, p.20557-20562
Main Authors: Cao, Qinglei, Deng, Zhongyuan, Liu, Juan, Li, Xiaolan
Format: Article
Language:English
Subjects:
Exercise
Gene expression
Genes
Muscles
Musculoskeletal system
Physical exercise
Probes
Sequential analysis
SGDB
Sports
sports gene
Visualization
Web servers
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Summary:The relationship between physical exercise and human health has been widely recognized by sports-related professionals and the public. However, the molecular mechanism behind sports remains unclear. A microarray sequencing technology has been widely used to detect gene changes after physical exercise and researchers have accumulated a great deal of data. These data provide a large amount of information for researchers to understand the relationship between genetics and exercise and study changes in genes after different forms of exercise, and their relations with human, gender and age. We integrate eight published gene expression datasets from human skeletal muscle and construct an online web server called SGDB standing for Sports Gene DataBase. SGDB can be used to search for genes that are expressed after exercise and no exercise. One can determine the effects of physical exercise on gene expression while allowing for visualization of changes in female and male. In addition, different forms of exercise and relationships with age are also available. Currently, SGDB contains 54613 annotated gene probes based on the Affymetrix Human Genome U133 Plus 2 Affay (GPL570). It has become one of the most important resources for researchers to study sports and genes. The online access address for SGDB is http://www.sportsgene.top.
ISSN:2169-3536
2169-3536
DOI:10.1109/ACCESS.2020.2968514