Design and evaluation of a nanoenhanced anti-infective calcium phosphate bone cements

Post-operative complications due to infections are the most common problems that occur following dental and orthopedic implant surgeries and bone repair procedures. Preventing post-surgical infections is therefore a critical need that current polymethylmethacrylate (PMMA) bone cement fail to address...

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Bibliographic Details
Main Authors: Tappa, Karthik K., Jammalamadaka, Udayabhanu M., Mills, David K.
Format: Conference Proceeding
Language:English
Subjects:
Antibiotics
Bones
Calcium
Mechanical factors
Scanning electron microscopy
Testing
Online Access:Request full text
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Description
Summary:Post-operative complications due to infections are the most common problems that occur following dental and orthopedic implant surgeries and bone repair procedures. Preventing post-surgical infections is therefore a critical need that current polymethylmethacrylate (PMMA) bone cement fail to address. Calcium phosphate cements (CPCs) are unique in their ability to crystallize calcium and phosphate salts into hydroxyapatite (HA) and hence is naturally osteoconductive. Due to its low mechanical strength its use in implant fixation and bone repair is limited to non-load bearing applications. The present work describes a new and novel antibiotic-doped clay nanotube CPC composite with enhanced mechanical properties as well as sustained release properties.
ISSN:1094-687X
1558-4615
2694-0604
DOI:10.1109/EMBC.2014.6944481