A microfluidic chip integrated with molecular imprinting polymer for surface plasmon resonance detection

This paper reports a microfluidic chip integrated with molecular imprinting polymers (MIP) for surface plasmon resonance (SPR) detection of specific label-free bio-samples. The innovative microfluidic biochip is capable of transporting a specific amount of bio-samples inside multiple microchannels u...

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Bibliographic Details
Main Authors: Shih-Chiang Huang, Jan-Sheng Lin, Shean-Jen Chen, Gwo-Bin Lee, Fan-Ching Chien, Wen-Janq Chen
Format: Conference Proceeding
Language:English
Subjects:
Microchannel
Microfluidics
Micropumps
Microvalves
Nitrogen
Optical polymers
Plasmons
Resonance
Temperature control
Temperature sensors
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Summary:This paper reports a microfluidic chip integrated with molecular imprinting polymers (MIP) for surface plasmon resonance (SPR) detection of specific label-free bio-samples. The innovative microfluidic biochip is capable of transporting a specific amount of bio-samples inside multiple microchannels using micropumps/micro valves to sensing regions where multiple MIP films are locally deposited such that highly-sensitive, highly-specific bio-sensing could be achieved. With the help of SPR sensing techniques, the microfluidic biochips have the potential to be widely used for bio-sensing applications. While compared to other sensing techniques, the developed system has several advantages, including labeling-free, high sensitivity, capability of quantitative analysis of nano-scale bio-molecules in real-time fashion.
ISSN:2159-547X
DOI:10.1109/SENSOR.2005.1497437