Osteocalcin And Osteonectin Expression After Doubleapplication Of Platelet-Rich Plasma In Rabbits

Purpose: Platelet-rich plasma (PRP) is a novel methodfor transferring autogenous growth factors to thewound area. The aim of this study was to evaluate theefficacy of double-application of PRP (DA-PRP) onbone healing in rabbit cranial defects by examiningosteonectin (ON) and osteocalcin (OC) express...

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Bibliographic Details
Published in:Journal of Istanbul University Faculty of Dentistry 2016-02, Vol.50 (2)
Main Authors: Özdemir,Burcu, Şengüven,Burcu, Yıldırım,Benay, Özcan,Gönen, Kurtiş,Bülent, Tüter,Gülay
Format: Article
Language:English
Subjects:
Diş Hekimliği
Tıp
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Summary:Purpose: Platelet-rich plasma (PRP) is a novel methodfor transferring autogenous growth factors to thewound area. The aim of this study was to evaluate theefficacy of double-application of PRP (DA-PRP) onbone healing in rabbit cranial defects by examiningosteonectin (ON) and osteocalcin (OC) expression.Materials and Methods: Twenty-eight rabbits, each with twosurgically prepared calvarial bone defects, were includedin this study and divided into six groups: The defects(N=56) were treated with either a single-application ofPRP (SA-PRP) (n=10), a combination of SA-PRP and betatricalciumphosphate(SA-PRP+β-TCP) (n=10), only DAPRP(n=8), both DA-PRP and beta-tricalciumphosphate(DA-PRP+β-TCP) (n=8), only beta-tricalciumphosphate(β-TCP) (n=10), or controls (n=10). The animals weresacrificed at 30th day postoperatively and samples wereimmunohistochemically examined for ON and OC expressions.Results: It was determined that DA-PRP did notsignificantly improve the ON and OC percentagesachieved by SA-PRP or the controls. The three groupstreated with β-TCP showed a higher percentage of ONthan those treated without β-TCP (p
ISSN:2149-2352
2149-4592
DOI:10.17096/jiufd.40536