Serum Autoantibodies to Desmogleins 1 and 3 in Patients with Oral Lichen Planus

Aim: To determine the presence of circulating autoantibodies to desmoglein (Dsg) 1 and Dsg 3 in patients with oral lichen planus. Methods: Serum concentrations of circulating autoantibodies to Dsg 1 and Dsg 3 were determined by ELISA in 32 patients with erosive form and 25 patients with reticular fo...

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Bibliographic Details
Published in:Croatian medical journal 2006-02, Vol.47 (1), p.53
Main Authors: Lukač, Josip, Brozović, Suzana, Vučićević-Boras, Vanja, Mravak-Stipetić, Marinka, Malenica, Branko, Kusić, Zvonko
Format: Article
Language:English
Subjects:
Desmoglein 1
Desmoglein 3
lichen planus, oral
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Summary:Aim: To determine the presence of circulating autoantibodies to desmoglein (Dsg) 1 and Dsg 3 in patients with oral lichen planus. Methods: Serum concentrations of circulating autoantibodies to Dsg 1 and Dsg 3 were determined by ELISA in 32 patients with erosive form and 25 patients with reticular form of oral lichen planus, 13 patients with acute recurrent aphthous ulcerations and 50 healthy controls. Indirect immunofluorescence analysis was also performed. Results: Concentrations of circulating autoantibodies to both Dsg 1 and Dsg 3 detected in the sera of patients with erosive form of oral lichen planus were significantly increased in comparison with those in healthy controls, patients with recurrent aphthous ulceration, and those with reticular oral lichen planus (P
ISSN:0353-9504
1332-8166