Fibrin sealant for early repair of acquired ventricular septal defect

The trend toward early operation for acquired ventricular septal defects exposes the patient to major perioperative bleeding and residual shunt because of the fragility of the recently necrosed myocardium. To reduce these complications we have used a fibrin sealant to reinforce the cardiac tissues i...

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Bibliographic Details
Published in:The Journal of thoracic and cardiovascular surgery 1992-09, Vol.104 (3), p.748-751
Main Authors: Seguin, J.R., Frapier, J- M., Colson, P., Chaptal, P.A.
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Cardiac & Cardiovascular Systems
Cardiovascular System & Cardiology
Female
Fibrin Tissue Adhesive
Follow-Up Studies
Heart Rupture, Post-Infarction - surgery
Heart Septum - surgery
Heart Ventricles - surgery
Humans
Life Sciences & Biomedicine
Male
Medical sciences
Polyethylene Terephthalates
Prostheses and Implants
Respiratory System
Science & Technology
Surgery
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the heart
Time Factors
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Summary:The trend toward early operation for acquired ventricular septal defects exposes the patient to major perioperative bleeding and residual shunt because of the fragility of the recently necrosed myocardium. To reduce these complications we have used a fibrin sealant to reinforce the cardiac tissues in addition to the usual closure of the defect with a Dacron patch through a left ventriculotomy in the infarcted area. During cardiac arrest fibrin sealant is applied on the ventricular septum around the defect, between the septum and the patch, and on the edges of the ventriculotomy. This technique was used in three patients (mean age 68.2 years) operated on for an acquired ventricular septal defect within 4 days of the infarction and within 24 hours of the occurrence of the defect. Low postoperative bleeding, absence of recurrent shunt, and good ventricular function indicated satisfactory surgical result in all three patients. We suggest that the use of fibrin sealant during operations for acquired ventricular septal defects, by reinforcing the necrotic and fragile tissues, may reduce perioperative bleeding and assure a more solid implantation of the patch. (J Thorac Cardiovasc Surg 1992;104:748-51)
ISSN:0022-5223
1097-685X
DOI:10.1016/S0022-5223(19)34746-4