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Exercise intensity-dependent contribution of β-adrenergic receptor-mediated vasodilatation in hypoxic humans
We previously reported that hypoxia-mediated reductions in α-adrenoceptor sensitivity do not explain the augmented vasodilatation during hypoxic exercise, suggesting an enhanced vasodilator signal. We hypothesized that β-adrenoceptor activation contributes to augmented hypoxic exercise vasodilatat...
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Published in: | The Journal of physiology 2008-02, Vol.586 (4), p.1195 |
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Main Authors: | , , , , , |
Format: | Article |
Language: | English |
Online Access: | Get full text |
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Summary: | We previously reported that hypoxia-mediated reductions in α-adrenoceptor sensitivity do not explain the augmented vasodilatation
during hypoxic exercise, suggesting an enhanced vasodilator signal. We hypothesized that β-adrenoceptor activation contributes
to augmented hypoxic exercise vasodilatation. Fourteen subjects (age: 29 ± 2 years) breathed hypoxic gas to titrate arterial
O 2 saturation (pulse oximetry) to 80%, while remaining normocapnic via a rebreath system. Brachial artery and antecubital vein
catheters were placed in the exercising arm. Under normoxic and hypoxic conditions, baseline and incremental forearm exercise
(10% and 20% of maximum) was performed during control (saline), α-adrenoceptor inhibition (phentolamine), and combined α-
and β-adrenoceptor inhibition (phentolomine/propranolol). Forearm blood flow (FBF), heart rate, blood pressure, minute ventilation,
and end-tidal CO 2 were determined. Hypoxia increased heart rate ( P < 0.05) and minute ventilation ( P < 0.05) at rest and exercise under all drug infusions, whereas mean arterial pressure was unchanged. Arterial adrenaline
( P < 0.05) and venous noradrenaline ( P < 0.05) were higher with hypoxia during all drug infusions. The change (Î) in FBF during 10% hypoxic exercise was greater
with phentolamine (Î306 ± 43 ml min â1 ) vs. saline (Î169 ± 30 ml min â1 ) or combined phentolamine/propranolol (Î213 ± 25 ml min â1 ; P < 0.05 for both). During 20% hypoxic exercise, ÎFBF was greater with phentalomine (Î466 ± 57 ml min â1 ; P < 0.05) vs. saline (Î346 ± 40 ml min â1 ) but was similar to combined phentolamine/propranolol (Î450 ± 43 ml min â1 ). Thus, in the absence of overlying vasoconstriction, the contribution of β-adrenergic mechanisms to the augmented hypoxic
vasodilatation is dependent on exercise intensity. |
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ISSN: | 0022-3751 1469-7793 |
DOI: | 10.1113/jphysiol.2007.144113 |