The Lactate Paradox in Human High-Altitude Physiological Performance

P. W. Hochachka 1 ,2 ,3 , C. L. Beatty 1 , Y. Burelle 1 , M. E. Trump 1 , D. C. McKenzie 3 and G. O. Matheson 4 1 Department of Zoology, 2 Department of Radiology, and 3 Sports Medicine Division, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada; and 4 Department of Functio...

Full description

Saved in:
Bibliographic Details
Published in:News in physiological sciences 2002-06, Vol.17 (3), p.122-126
Main Authors: Hochachka, P. W, Beatty, C. L, Burelle, Y, Trump, M. E, McKenzie, D. C, Matheson, G. O
Format: Article
Language:English
Subjects:
Acclimatization - physiology
Altitude
Exercise - physiology
Humans
Lactic Acid - blood
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:P. W. Hochachka 1 ,2 ,3 , C. L. Beatty 1 , Y. Burelle 1 , M. E. Trump 1 , D. C. McKenzie 3 and G. O. Matheson 4 1 Department of Zoology, 2 Department of Radiology, and 3 Sports Medicine Division, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada; and 4 Department of Functional Restoration, Sports Medicine Division, Stanford University, Stanford, California 94305-6175 For many years, physiologists have puzzled over the observation that, during maximum aerobic exercise, high-altitude natives generate lower-than-expected amounts of lactate; the higher the altitude, the lower the postexercise blood lactate peak. This paradoxical situation may be caused mainly by upregulated metabolic control contributions from cell ATP demand and ATP supply pathways.
ISSN:1548-9213
0886-1714
1548-9221
1522-161X
DOI:10.1152/nips.01382.2001