The Intrarenal Endothelin System and Hypertension

Zaid A. Abassi 1 , Samer Ellahham 2 ,3 , Joseph Winaver 1 and Aaron Hoffman 4 1 Department of Physiology and Biophysics, Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology and 4 Department of Vascular Surgery and Transplantation, Rambam Medical Center, 31096 Haifa, Israel;...

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Bibliographic Details
Published in:News in physiological sciences 2001-08, Vol.16 (4), p.152-156
Main Authors: Abassi, Zaid A, Ellahham, Samer, Winaver, Joseph, Hoffman, Aaron
Format: Article
Language:English
Subjects:
Animals
Diuresis - physiology
Endothelin-1 - physiology
Endothelins - physiology
Humans
Hypertension - physiopathology
Kidney - physiopathology
Kidney Medulla - physiopathology
Natriuresis - physiology
Receptor, Endothelin B
Receptors, Endothelin - physiology
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Summary:Zaid A. Abassi 1 , Samer Ellahham 2 ,3 , Joseph Winaver 1 and Aaron Hoffman 4 1 Department of Physiology and Biophysics, Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology and 4 Department of Vascular Surgery and Transplantation, Rambam Medical Center, 31096 Haifa, Israel; and 2 Exercise and Pharmacological Stress Imaging Laboratory and 3 Vascular Biology Laboratory, Division of Cardiology, Washington Hospital Center, Washington, DC 20010 The kidney is both a source of endothelin (ET) generation and an important target organ of this peptide. The highest concentrations of ET-1 in the body exist in the renal medulla, where it mediates natriuretic and diuretic effects through the ET B receptor subtype. It is proposed that aberrations in the renal ET system may lead to sodium and water retention and subsequently to the development of hypertension.
ISSN:1548-9213
0886-1714
1548-9221
1522-161X
DOI:10.1152/physiologyonline.2001.16.4.152