Effect of antioxidant vitamin treatment on the time course of hematological and hemorheological alterations after an exhausting exercise episode in human subjects

1 Department of Physiology, Akdeniz University Faculty of Medicine, Antalya, Turkey; and 2 Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, California Submitted 12 August 2004 ; accepted in final form 29 November 2004 This study examin...

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Published in:Journal of applied physiology (1985) 2005-04, Vol.98 (4), p.1272-1279
Main Authors: Senturk, Umit K, Yalcin, Ozlem, Gunduz, Filiz, Kuru, Oktay, Meiselman, Herbert J, Baskurt, Oguz K
Format: Article
Language:English
Subjects:
Adaptation, Physiological - drug effects
Adaptation, Physiological - physiology
Administration, Oral
Adult
Antioxidants
Antioxidants - administration & dosage
Biological and medical sciences
Blood
Blood Cell Count
Blood Physiological Phenomena
Erythrocyte Deformability - physiology
Erythrocytes - physiology
Exercise
General and cellular metabolism. Vitamins
Hemostasis - drug effects
Hemostasis - physiology
Humans
Lipid Peroxidation - physiology
Male
Medical sciences
Mortality
Oxidative Stress - physiology
Pharmacology. Drug treatments
Physical Endurance - physiology
Physical Exertion - physiology
Physical Fitness - physiology
Time Factors
Vitamins - administration & dosage
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Summary:1 Department of Physiology, Akdeniz University Faculty of Medicine, Antalya, Turkey; and 2 Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, California Submitted 12 August 2004 ; accepted in final form 29 November 2004 This study examined the effects of a 2-mo antioxidant vitamin treatment on acute hematological and hemorheological alterations induced by exhausting exercise; both sedentary and trained individuals were employed. Eighteen young male, human subjects (9 sedentary, 9 trained by regular exercise) participated in the study and performed an initial maximal aerobic cycle ergometer exercise with frequent blood sampling over a 24-h period and analysis of hematological and hemorheological parameters. All subjects were treated with an antioxidant vitamin A, C, and E regimen, supplemented orally for 2 mo, and then subjected to a second exercise test and blood sampling at the end of this period. In the sedentary group during the first testing period (before vitamin treatment), white blood cell counts and granulocyte percentages were increased at 2 h after the exercise test and remained elevated for 4–12 h. Red blood cell (RBC) deformability and aggregation were also altered by exercise in the sedentary group before vitamin treatment. However, none of these parameters in the sedentary group were altered by exercise after the 2-mo period of antioxidant vitamin treatment. With the exception of a transient rise in granulocyte percentage, these parameters were also not affected in the trained subjects before the vitamin treatment. Significant increases of RBC lipid peroxidation observed 12 h after the exercise test in both sedentary and trained subjects were also totally prevented by vitamin treatment. Our results indicate that antioxidant vitamin treatment is effective in preventing the inflammation-like response and coincident adverse hemorheological changes after an episode of exhausting exercise, and suggest that such changes may be related to exercise-induced death events. erythrocyte deformability; erythrocyte aggregation; inflammatory response; exercise-related mortality Address for reprint requests and other correspondence: O. K. Baskurt, Dept. of Physiology, Akdeniz Univ., Faculty of Medicine, Kampus, Antalya, Turkey (E-mail: baskurt{at}akdeniz.edu.tr )
ISSN:8750-7587
1522-1601
DOI:10.1152/japplphysiol.00875.2004