fMRI responses to cold pressor challenges in control and obstructive sleep apnea subjects

Departments of 1  Neurobiology, 4  Radiology, and 5  Neurology, 3  School of Nursing, and 2  Brain Research Institute, University of California at Los Angeles, Los Angeles, California 90095 Obstructive sleep apnea (OSA) patients exhibit altered sympathetic outflow, which may reveal mechanisms underl...

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Bibliographic Details
Published in:Journal of applied physiology (1985) 2003-04, Vol.94 (4), p.1583-1595
Main Authors: Harper, Ronald M, Macey, Paul M, Henderson, Luke A, Woo, Mary A, Macey, Katherine E, Frysinger, Robert C, Alger, Jeffry R, Nguyen, Khanh P, Yan-Go, Frisca L
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Blood Pressure
Brain - physiopathology
Case-Control Studies
Cluster Analysis
Cold Temperature
Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes
Heart Rate
Humans
Magnetic Resonance Imaging
Male
Medical sciences
Middle Aged
Nervous system (semeiology, syndromes)
Neurology
Respiratory Mechanics
Sleep Apnea Syndromes - diagnosis
Sleep Apnea Syndromes - physiopathology
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Summary:Departments of 1  Neurobiology, 4  Radiology, and 5  Neurology, 3  School of Nursing, and 2  Brain Research Institute, University of California at Los Angeles, Los Angeles, California 90095 Obstructive sleep apnea (OSA) patients exhibit altered sympathetic outflow, which may reveal mechanisms underlying the syndrome. We used functional MRI (fMRI) in 16 control and 10 OSA subjects who were free of cardiovascular or mood-altering drugs to examine neural responses to a forehead cold pressor challenge, which elicits respiratory slowing, bradycardia, and enhanced sympathetic outflow. The magnitude of cold-induced bradycardia was smaller, and respiratory slowing showed greater intersubject variability and reached a nadir later in OSA patients. Both groups showed similar signal changes to cold stimulation in multiple brain sites. However, signal increases emerged in OSA over controls in anterior and posterior cingulate and cerebellar and frontal cortex, whereas signals markedly declined in the ventral thalamus, hippocampus, and insula rather than rising as in controls. Anomalous responses often paralleled changes in breathing and heart rate. Medullary, midbrain areas and lentiform and cerebellar dentate nuclei also showed lower signals in OSA cases. Cold pressor physiological responses are modified in OSA and may result from both diminished and exaggerated responses in multiple brain structures. heart rate; respiration; autonomic; dive reflex; functional magnetic resonance imaging
ISSN:8750-7587
1522-1601
DOI:10.1152/japplphysiol.00881.2002