Glucose ingestion during endurance training does not alter adaptation

1 Centre of Inflammation and Metabolism, Department of Infectious Diseases and Copenhagen Muscle Research Centre, Rigshospitalet and Faculty of Health Sciences, University of Copenhagen; 2 Department of Radiology, Rigshospitalet, University of Copenhagen; and 3 Department of Biomedical Sciences, Uni...

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Published in:Journal of applied physiology (1985) 2009-06, Vol.106 (6), p.1771-1779
Main Authors: Akerstrom, Thorbjorn C. A, Fischer, Christian P, Plomgaard, Peter, Thomsen, Carsten, van Hall, Gerrit, Pedersen, Bente Klarlund
Format: Article
Language:English
Subjects:
3-Hydroxyacyl CoA Dehydrogenases - metabolism
Adaptation, Physiological - drug effects
Adaptation, Physiological - physiology
Adult
Biological and medical sciences
Citrate (si)-Synthase - metabolism
Energy Metabolism - drug effects
Enzymes
Exercise
Exercise Test
Fatigue
Fatty acids
Fundamental and applied biological sciences. Psychology
Glucose
Glucose - administration & dosage
Glycogen - metabolism
Humans
Male
Metabolism
Musculoskeletal system
Oxidation
Oxidation-Reduction
Palmitates - metabolism
Physical Endurance - drug effects
Physical Endurance - physiology
Quadriceps Muscle - anatomy & histology
Quadriceps Muscle - drug effects
Quadriceps Muscle - metabolism
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Summary:1 Centre of Inflammation and Metabolism, Department of Infectious Diseases and Copenhagen Muscle Research Centre, Rigshospitalet and Faculty of Health Sciences, University of Copenhagen; 2 Department of Radiology, Rigshospitalet, University of Copenhagen; and 3 Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark Submitted 25 November 2008 ; accepted in final form 15 February 2009 Glucose ingestion during exercise attenuates activation of metabolic enzymes and expression of important transport proteins. In light of this, we hypothesized that glucose ingestion during training would result in 1 ) an attenuation of the increase in fatty acid uptake and oxidation during exercise, 2 ) lower citrate synthase (CS) and β-hydroxyacyl-CoA dehydrogenase (β-HAD) activity and glycogen content in skeletal muscle, and 3 ) attenuated endurance performance enhancement in the trained state. To investigate this we studied nine male subjects who performed 10 wk of one-legged knee extensor training. They trained one leg while ingesting a 6% glucose solution (Glc) and ingested a sweetened placebo while training the other leg (Plc). The subjects trained their respective legs 2 h at a time on alternate days 5 days a week. Endurance training increased peak power (P max ) and time to fatigue at 70% of P max 14% and 30%, respectively. CS and β-HAD activity increased and glycogen content was greater after training, but there were no differences between Glc and Plc. After training the rate of oxidation of palmitate (R ox ) and the % of rate of disappearance that was oxidized (%R dox ) changed. %R dox was on average 16.4% greater during exercise after training whereas, after exercise %R dox was 30.4% lower. R ox followed the same pattern. However, none of these parameters were different between Glc and Plc. We conclude that glucose ingestion during training does not alter training adaptation related to substrate metabolism, mitochondrial enzyme activity, glycogen content, or performance. metabolism; skeletal muscle; performance Address for reprint requests and other correspondence: T. C. A. Akerstrom, Centre of Inflammation and Metabolism and Copenhagen Muscle Research Centre, Rigshospitalet-7641, Blegdamsvej 9, DK-2100 Copenhagen, Denmark (e-mail: thorbjorn_akerstrom{at}inflammation-metabolism.dk )
ISSN:8750-7587
1522-1601
DOI:10.1152/japplphysiol.91534.2008