Ca2+ handling in isolated human atrial myocardium

1  Abteilung Kardiologie und Pneumologie, Zentrum Innere Medizin, and 2  Abteilung Thorax-, Herz-, Gefäßchirurgie, Zentrum Chirurgie, Georg-August-Universität Göttingen, 37075 Göttingen, Germany Physiologically, human atrial and ventricular myocardium are coupled by an identical beating rate and rhy...

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Bibliographic Details
Published in:American journal of physiology. Heart and circulatory physiology 2000-09, Vol.279 (3), p.H952
Main Authors: Maier, Lars S, Barckhausen, Paul, Weisser, Jutta, Aleksic, Ivo, Baryalei, Mersa, Pieske, Burkert
Format: Article
Language:English
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Summary:1  Abteilung Kardiologie und Pneumologie, Zentrum Innere Medizin, and 2  Abteilung Thorax-, Herz-, Gefäßchirurgie, Zentrum Chirurgie, Georg-August-Universität Göttingen, 37075 Göttingen, Germany Physiologically, human atrial and ventricular myocardium are coupled by an identical beating rate and rhythm. However, contractile behavior in atrial myocardium may be different from that in ventricular myocardium, and little is known about intracellular Ca 2+ handling in human atrium under physiological conditions. We used rapid cooling contractures (RCCs) to assess sarcoplasmic reticulum (SR) Ca 2+ content and the photoprotein aequorin to assess intracellular Ca 2+ transients in atrial and ventricular muscle strips isolated from nonfailing human hearts. In atrial myocardium ( n  = 19), isometric twitch force frequency dependently (0.25-3 Hz) increased by 78   ± 25% (at 3 Hz; P  
ISSN:0363-6135
1522-1539