Sympathetic innervation modulates repolarizing K+ currents in rat epicardial myocytes

1  Departments of Pharmacology and Pediatrics, College of Physicians and Surgeons of Columbia University, New York 10032; and 2  Department of Neurobiology and Behavior, State University of New York at Stony Brook, Stony Brook, New York 11794-8661 During postnatal development, sympathetic innervatio...

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Published in:American journal of physiology. Heart and circulatory physiology 1998-03, Vol.274 (3), p.H915-H922
Main Authors: Liu, Qin-Yue, Rosen, Michael R, McKinnon, David, Robinson, Richard B
Format: Article
Language:English
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Summary:1  Departments of Pharmacology and Pediatrics, College of Physicians and Surgeons of Columbia University, New York 10032; and 2  Department of Neurobiology and Behavior, State University of New York at Stony Brook, Stony Brook, New York 11794-8661 During postnatal development, sympathetic innervation of the heart evolves, and repolarization accelerates. Our goal in this study was to test whether sympathetic innervation modulates the ion channels that regulate repolarization. We studied action potentials and repolarizing K + currents in epicardial myocytes from rats in which sympathetic innervation was accelerated or delayed, respectively, by subcutaneous injection of nerve growth factor (NGF) or NGF antibody (Ab) for the first 15 days of life. A placebo group was included as well. Action potential duration (APD) to 90% repolarization was greater in the Ab (158 ± 18 ms)-treated than the NGF (106 ± 10 ms)-treated animals ( P  
ISSN:0363-6135
1522-1539
DOI:10.1152/ajpheart.1998.274.3.h915