L-Carnitine L-tartrate supplementation favorably affects markers of recovery from exercise stress

1  Human Performance Laboratory, University of Connecticut, Storrs, Connecticut 06269; and 2  Lonza Incorporated, Fair Lawn, New Jersey 07410 We examined the influence of L -carnitine L -tartrate (LCLT) on markers of purine catabolism, free radical formation, and muscle tissue disruption after squat...

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Published in:American journal of physiology: endocrinology and metabolism 2002-02, Vol.282 (2), p.E474-E482
Main Authors: Volek, Jeff S, Kraemer, William J, Rubin, Martyn R, Gomez, Ana L, Ratamess, Nicholas A, Gaynor, Paula
Format: Article
Language:English
Subjects:
Adult
Biomarkers
Carnitine - blood
Cross-Over Studies
Cytosol - metabolism
Double-Blind Method
Exercise - physiology
Free Radicals - metabolism
Humans
Lactic Acid - blood
Magnetic Resonance Imaging
Male
Muscle, Skeletal - pathology
Muscle, Skeletal - physiopathology
Pain - physiopathology
Proteins - metabolism
Purines - metabolism
Stress, Physiological - etiology
Stress, Physiological - metabolism
Stress, Physiological - physiopathology
Tartrates - pharmacology
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Summary:1  Human Performance Laboratory, University of Connecticut, Storrs, Connecticut 06269; and 2  Lonza Incorporated, Fair Lawn, New Jersey 07410 We examined the influence of L -carnitine L -tartrate (LCLT) on markers of purine catabolism, free radical formation, and muscle tissue disruption after squat exercise. With the use of a balanced, crossover design (1 wk washout), 10 resistance-trained men consumed a placebo or LCLT supplement (2 g L -carnitine/day) for 3 wk before obtaining blood samples on six consecutive days (D1 to D6). Blood was also sampled before and after a squat protocol (5 sets, 15-20 repetitions) on D2. Muscle tissue disruption at the midthigh was assessed using magnetic resonance imaging (MRI) before exercise and on D3 and D6. Exercise-induced increases in plasma markers of purine catabolism (hypoxanthine, xanthine oxidase, and serum uric acid) and circulating cytosolic proteins (myoglobin, fatty acid-binding protein, and creatine kinase) were significantly ( P    0.05) attenuated by LCLT. Exercise-induced increases in plasma malondialdehyde returned to resting values sooner during LCLT compared with placebo. The amount of muscle disruption from MRI scans during LCLT was 41-45% of the placebo area. These data indicate that LCLT supplementation is effective in assisting recovery from high-repetition squat exercise. hypoxia; ergogenic aid; resistance exercise; muscle damage
ISSN:0193-1849
1522-1555
DOI:10.1152/ajpendo.00277.2001