Human aging is associated with parallel reductions in insulin and amylin release

Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington, Seattle 98195; and Veterans Affairs Puget Sound Health Care System, Seattle, Washington 98108 Aging is associated with an increased risk of type 2 diabetes. To determine whether the insulin resista...

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Published in:American journal of physiology: endocrinology and metabolism 1998-11, Vol.275 (5), p.E785-E791
Main Authors: Dechenes, Cynthia J, Verchere, C. Bruce, Andrikopoulos, Sofianos, Kahn, Steven E
Format: Article
Language:English
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Summary:Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington, Seattle 98195; and Veterans Affairs Puget Sound Health Care System, Seattle, Washington 98108 Aging is associated with an increased risk of type 2 diabetes. To determine whether the insulin resistance of aging is associated with an increase in amylin release or whether amylin release parallels the reduction in insulin release, we studied 10 older (72 ± 2   yr) and 9 young (25 ± 1 yr) subjects. Insulin sensitivity was quantified as the insulin sensitivity index (S I ) and B cell function as the acute insulin and amylin responses to iv glucose (AIRg and AARg, respectively) and iv arginine at a glucose level of >25 mM (AIRmax and AARmax). To account for the effect of S I to modulate B cell function, we calculated S I  × B cell function. Older subjects were insulin resistant (S I : 4.6 ± 0.8 vs. 8.6 ±   1.4 × 10 5 min 1 /pM, P  
ISSN:0193-1849
1522-1555
DOI:10.1152/ajpendo.1998.275.5.E785