Production of parathyroid hormone-related protein by the rat mammary gland in pregnancy and lactation

M. Rakopoulos, S. J. Vargas, M. T. Gillespie, P. W. Ho, H. Diefenbach-Jagger, D. D. Leaver, V. Grill, J. M. Moseley, J. A. Danks and T. J. Martin St. Vincent's Institute of Medical Research, Fitzroy, Victoria, Australia. Production of parathyroid hormone-related protein by the rat mammary gland...

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Published in:American journal of physiology: endocrinology and metabolism 2006-01, Vol.263 (6), p.E1077-E1085
Main Authors: Rakopoulos, M, Vargas, S. J, Gillespie, M. T, Ho, P. W, Diefenbach-Jagger, H, Leaver, D. D, Grill, V, Moseley, J. M, Danks, J. A, Martin, T. J
Format: Article
Language:English
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Summary:M. Rakopoulos, S. J. Vargas, M. T. Gillespie, P. W. Ho, H. Diefenbach-Jagger, D. D. Leaver, V. Grill, J. M. Moseley, J. A. Danks and T. J. Martin St. Vincent's Institute of Medical Research, Fitzroy, Victoria, Australia. Production of parathyroid hormone-related protein by the rat mammary gland in pregnancy and lactation. Am. J. Physiol. 263 (Endocrinol. Metab. 26): E1077-E1085, 1992.--Production of parathyroid hormone-related protein (PTHrP) by the mammary gland of Sprague-Dawley rats has been examined using immunohistochemistry and in situ hybridization to detect PTHrP and PTHrP mRNA, respectively. PTHrP and PTHrP mRNA could be demonstrated in nests of epithelial cells of the developing mammary gland at day 14 of pregnancy and in the epithelial secretory cells lining the alveoli during the latter stages of pregnancy and during lactation. A specific radioimmunoassay was also used to measure the concentration of PTHrP secreted in the milk throughout lactation. The concentration of PTHrP in milk was relatively low initially but increased during the latter stages of lactation, whereas calcium concentrations remained virtually constant throughout lactation. No correlation was found between the concentrations of calcium and PTHrP in rat milk. These results show that PTHrP is present in rat milk and also in mammary tissue before parturition, and therefore it may assist in the development of the mammary gland during pregnancy.
ISSN:0193-1849
1522-1555
DOI:10.1152/ajpendo.2006.263.6.E1077