Bovine papillomavirus E1 protein can, by itself, efficiently drive multiple rounds of DNA synthesis in vitro

Bovine papillomavirus E1 protein was found to be as efficient as the simian virus 40 large T antigen in initiating DNA synthesis in a cell-free system derived from COS1 cells. Multiple rounds of DNA synthesis occur, initiated at the bovine papillomavirus type 1 origin. Therefore, E1 functions in vit...

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Bibliographic Details
Published in:Journal of Virology 1995-05, Vol.69 (5), p.3201-3205
Main Authors: Bonne-Andrea, C. (INSERM, Nice, France.), Santucci, S, Clertant, P
Format: Article
Language:English
Subjects:
ADN
Animals
Antigens, Polyomavirus Transforming - metabolism
Bovine papillomavirus 1 - genetics
Bovine papillomavirus 1 - metabolism
Bovine papillomavirus 1 - physiology
Cattle
Cell Line
DNA Replication - genetics
DNA, Viral - biosynthesis
DNA-Binding Proteins - metabolism
EXPERIMENTACION IN VITRO
EXPERIMENTATION IN VITRO
In Vitro Techniques
Life Sciences
PAPILLOMAVIRUS BOVIN
PROTEINAS
PROTEINE
Replication Origin
Simian virus 40 - metabolism
Viral Proteins - metabolism
VIRUS DE LOS ANIMALES
VIRUS DEL PAPILOMA BOVINO
VIRUS DES ANIMAUX
Virus Replication
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Description
Summary:Bovine papillomavirus E1 protein was found to be as efficient as the simian virus 40 large T antigen in initiating DNA synthesis in a cell-free system derived from COS1 cells. Multiple rounds of DNA synthesis occur, initiated at the bovine papillomavirus type 1 origin. Therefore, E1 functions in vitro as a lytic virus initiator
ISSN:0022-538X
1098-5514
DOI:10.1128/JVI.69.5.3201-3205.1995