Impact of MenBvac, an outer membrane vesicle (OMV) vaccine, on the meningococcal carriage

Highlights • We conducted a meningococcal carriage study among children aged 1–7 years old. • We evaluated the impact of MenBvac, an outer membrane vesicle (OMV) vaccine, on the pharyngeal meningococcal carriage. • MenBvac reduces meningococcal carriage and may hence confer herd immunity. • The nove...

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Bibliographic Details
Published in:Vaccine 2013-09, Vol.31 (40), p.4416-4420
Main Authors: Delbos, Valérie, Lemée, Ludovic, Bénichou, Jacques, Berthelot, Gilles, Deghmane, Ala-Eddine, Leroy, Jean-Philippe, Houivet, Estelle, Hong, Eva, Taha, Muhamed-Kheir, Caron, François
Format: Article
Language:English
Subjects:
Acquisitions & mergers
Adolescent
Allergy and Immunology
Animals
Antibodies, Bacterial
Antibodies, Bacterial - blood
Applied microbiology
Asymptomatic Infections
Bacterial Outer Membrane Proteins
Bacterial Outer Membrane Proteins - immunology
Bacteriology
Biological and medical sciences
Carriage
Child
Child, Preschool
Children
Confidence intervals
France
Fundamental and applied biological sciences. Psychology
herds
Humans
immunity
Immunology
Infant
Life Sciences
Meningitis
Meningitis, Meningococcal
Meningitis, Meningococcal - immunology
Meningitis, Meningococcal - prevention & control
Meningococcal Vaccines
Meningococcal Vaccines - administration & dosage
Meningococcal Vaccines - immunology
Meningococci
Mice
Microbiology
Miscellaneous
Multivariate analysis
Neisseria meningitidis
Neisseria meningitidis - immunology
Outbreak
Outer membrane vesicle vaccine
serotypes
Software
vaccination
Vaccines
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
Vaccinology
volunteers
Young Adult
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Summary:Highlights • We conducted a meningococcal carriage study among children aged 1–7 years old. • We evaluated the impact of MenBvac, an outer membrane vesicle (OMV) vaccine, on the pharyngeal meningococcal carriage. • MenBvac reduces meningococcal carriage and may hence confer herd immunity. • The novel meningococcal B vaccine that includes an OMV component may have an impact on carriage.
ISSN:0264-410X
1873-2518
0264-410X
DOI:10.1016/j.vaccine.2013.06.080