Genomic characterizations of bat coronaviruses (1A, 1B and HKU8) and evidence for co-infections in Miniopterus bats

1 State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, The University of Hong Kong, Hong Kong SAR 2 HKU-Pasteur Research Centre, Hong Kong SAR Correspondence J. S. M. Peiris malik{at}hkucc.hku.hk We previously reported the detection of bat coronaviruses (bat CoVs 1A, 1B,...

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Published in:	Journal of general virology 2008-05, Vol.89 (5), p.1282-1287
Main Authors:	Chu, D. K. W, Peiris, J. S. M, Chen, H, Guan, Y, Poon, L. L. M
Format:	Article
Language:	eng
Subjects:	Animals Biological and medical sciences Chiroptera Chiroptera - virology Coronavirus Coronavirus - genetics Coronavirus - isolation & purification Coronavirus Infections Coronavirus Infections - veterinary Coronavirus Infections - virology Fundamental and applied biological sciences. Psychology Genome, Viral Hong Kong Life Sciences Microbiology Microbiology and Parasitology Miniopterus Miscellaneous Molecular Sequence Data Phylogeny Sequence Analysis, DNA Sequence Homology Virology
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Summary:	1 State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, The University of Hong Kong, Hong Kong SAR 2 HKU-Pasteur Research Centre, Hong Kong SAR Correspondence J. S. M. Peiris malik{at}hkucc.hku.hk We previously reported the detection of bat coronaviruses (bat CoVs 1A, 1B, HKU7, HKU8 and bat-severe acute respiratory syndrome coronavirus) in Miniopterus spp. that cohabit a cave in Hong Kong. Here, we report the full genomic sequences of bat CoVs 1A, 1B and HKU8. Bat CoVs 1A and 1B, which are commonly found in the Miniopterus , are phylogenetically closely related. Using species-specific RT-PCR assays, bat CoVs 1A and 1B were confirmed to have distinct host specificities to Miniopterus magnater and Miniopterus pusillus , respectively. Interestingly, co-infections of bat CoVs 1B and HKU8 in M. pusillus are detected in seven of 38 virus-positive specimens collected from 2004 to 2006. These findings highlight that co-infections of some coronaviruses might be common events in nature. The biological basis for the host restriction of bat coronaviruses, however, is yet to be determined. The GenBank/EMBL/DDBJ accession numbers for the sequences reported in this paper are EU420137–EU420139. Supplementary material is available with the online version of this paper.
ISSN:	0022-1317 1465-2099