Canine adenoviruses elicit both humoral and cell-mediated immune responses against rabies following immunisation of sheep

Abstract Safe and efficient vaccination is important for rabies prevention in domestic animals. Replicative vectors expressing the rabies virus glycoprotein, derived from canine adenovirus have been reported to be promising vaccines in various animal models. In this paper we compare the potential of...

Full description

Saved in:
Bibliographic Details
Published in:Vaccine 2011-02, Vol.29 (6), p.1304-1310
Main Authors: Bouet-Cararo, Coraline, Contreras, Vanessa, Fournier, Annie, Jallet, Corinne, Guibert, Jean Michel, Dubois, Eric, Thiery, Richard, Bréard, Emmanuel, Tordo, Noël, Richardson, Jennifer, Schwartz-Cornil, Isabelle, Zientara, Stéphan, Klonjkowski, Bernard
Format: Article
Language:English
Subjects:
Adenovirus
Adenoviruses, Canine - genetics
Allergy and Immunology
animal models
Animals
Antibodies, Neutralizing - blood
Antibodies, Viral - blood
Applied microbiology
Biological and medical sciences
Canine adenovirus
Canine adenovirus 2
Canine adenovirus A
CD4-Positive T-Lymphocytes - immunology
CD8-Positive T-Lymphocytes - immunology
Cell Proliferation
Deoxyribonucleic acid
DNA
dogs
Drug Carriers
Fundamental and applied biological sciences. Psychology
Genetic Vectors
glycoproteins
immune response
Infections
interferon-gamma
Interferon-gamma - secretion
Life Sciences
lymphocyte proliferation
Male
Mammals
Microbiology
Microbiology and Parasitology
Miscellaneous
neutralizing antibodies
Ovine
Rabies
Rabies - prevention & control
Rabies Vaccines - genetics
Rabies Vaccines - immunology
Rabies virus
Rabies virus - genetics
Rabies virus - immunology
Ruminantia
Sheep
Studies
vaccination
Vaccine
Vaccines
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
Vaccines, Attenuated - genetics
Vaccines, Attenuated - immunology
Vaccines, Inactivated - genetics
Vaccines, Inactivated - immunology
Vaccines, Synthetic - genetics
Vaccines, Synthetic - immunology
Virology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Safe and efficient vaccination is important for rabies prevention in domestic animals. Replicative vectors expressing the rabies virus glycoprotein, derived from canine adenovirus have been reported to be promising vaccines in various animal models. In this paper we compare the potential of a replicative and a non-replicative vector, both based on canine adenovirus type 2 and expressing the rabies glycoprotein. Upon inoculation in sheep, immune responses against the rabies virus protein elicited by recombinant vectors were monitored. All immunised sheep produced a rapid and potent neutralizing antibody response against rabies virus after a single inoculation of either replicative or non-replicative recombinant canine adenovirus type 2. In addition, the non-replicative vector expressing the rabies glycoprotein stimulated antigen-specific CD4+ and CD8+ lymphocyte proliferation as well as IFN-γ production. These results suggest that vectors derived from canine adenovirus 2 could be considered for the development of promising vaccines in the ruminant species.
ISSN:0264-410X
1873-2518
0264-410X
DOI:10.1016/j.vaccine.2010.11.068