Parental smoking, maternal alcohol, coffee and tea consumption and the risk of childhood brain tumours: the ESTELLE and ESCALE studies (SFCE, France)

Purpose To investigate whether parental smoking around the time of pregnancy or maternal consumption of beverages (alcohol, coffee, or tea) during pregnancy were associated with the risk of CBT. Methods We pooled data from two French national population-based case–control studies with similar design...

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Bibliographic Details
Published in:Cancer causes & control 2017-07, Vol.28 (7), p.719-732
Main Authors: Bailey, Helen D., Lacour, Brigitte, Guerrini-Rousseau, Léa, Bertozzi, Anne-Isabelle, Leblond, Pierre, Faure-Conter, Cécile, Pellier, Isabelle, Freycon, Claire, Doz, François, Puget, Stéphanie, Ducassou, Stéphane, Orsi, Laurent, Clavel, Jacqueline
Format: Article
Language:English
Subjects:
Adolescent
Adult
Alcohol
Alcohol Drinking
Alcoholic beverages
Alcohols
Astrocytoma
Astrocytoma - epidemiology
Beverages
Biomedical and Life Sciences
Biomedicine
Brain cancer
Brain Neoplasms - epidemiology
Brain tumors
Cancer
Cancer Research
Case-Control Studies
Child
Child, Preschool
Children
Cigarettes
Coffee
Confidence intervals
Consumption
Drinking behavior
Epidemiology
Fathers
Female
France - epidemiology
Gender
Hematology
Humans
Infant
Infant, Newborn
Life Sciences
Logistic Models
Male
Mothers
Odds Ratio
Oncology
ORIGINAL PAPER
Population studies
Pregnancy
Public Health
Risk Factors
Smoking
Statistical analysis
Tea
Tumors
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Summary:Purpose To investigate whether parental smoking around the time of pregnancy or maternal consumption of beverages (alcohol, coffee, or tea) during pregnancy were associated with the risk of CBT. Methods We pooled data from two French national population-based case–control studies with similar designs conducted in 2003–2004 and 2010–2011. The mothers of 510 CBT cases (directly recruited from the national childhood cancer register) and 3,102 controls aged under 15 years, frequency matched by age and gender, were interviewed through telephone, which included questions about prenatal parental smoking and maternal consumption of alcohol, coffee and tea. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using unconditional logistic regression, adjusted for age, sex and study of origin. Results No association was seen between CBT and the mother smoking or drinking alcohol, coffee, or tea during the index pregnancy. The OR between CBT and paternal smoking in the year before birth (as reported by the mother) was 1.25 (95% CI 1.03, 1.52) with an OR of 1.09 (0.99, 1.19) for every 10 cigarettes per day (CPD) smoked. The association between paternal smoking and CBT appeared to be stronger in children diagnosed before the age of five years (OR 1.52, 95% CI 1.14, 2.02) and for astrocytoma (OR 1.86, 95% CI 1.26, 2.74). Conclusion We found some evidence of a weak association between paternal smoking in the year before the child’s birth and CBT, especially astrocytomas. These findings need to be replicated in other samples, using similar classifications of tumour subtypes.
ISSN:0957-5243
1573-7225
DOI:10.1007/s10552-017-0900-4