Tropism and virulence of Cutibacterium (formerly Propionibacterium) acnes involved in implant-associated infection

The recognition of the pathogenicity of Cutibacterium acnes in implant-associated infection is not always obvious. In this paper, we aimed to distinguish pathogenic and non-pathogenic C. acnes isolates. To reach this goal, we investigated the clonal complex (CC) of a large collection of C. acnes cli...

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Bibliographic Details
Published in:Anaerobe 2017-10, Vol.47, p.73-78
Main Authors: Aubin, Guillaume Ghislain, Lavigne, Jean-Philippe, Foucher, Yohan, Dellière, Sarah, Lepelletier, Didier, Gouin, François, Corvec, Stéphane
Format: Article
Language:English
Subjects:
Animals
Caenorhabditis elegans
Caenorhabditis elegans - microbiology
Caenorhabditis elegans - physiology
Cancer
Cutibacterium (Propionibacterium) acnes
Disease Models, Animal
Diversilab
Gram-Positive Bacterial Infections - microbiology
Humans
Life Sciences
Multi-Locus Sequence Typing
Multilocus Sequence Typing
Propionibacterium acnes - classification
Propionibacterium acnes - genetics
Propionibacterium acnes - pathogenicity
Propionibacterium acnes - physiology
Prosthesis-Related Infections - microbiology
Prosthetic joint infections
Survival Analysis
Viral Tropism
Virulence
Virulence Factors - analysis
Virulence Factors - genetics
Whole Genome Sequencing
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Summary:The recognition of the pathogenicity of Cutibacterium acnes in implant-associated infection is not always obvious. In this paper, we aimed to distinguish pathogenic and non-pathogenic C. acnes isolates. To reach this goal, we investigated the clonal complex (CC) of a large collection of C. acnes clinical isolates through Multi-Locus Sequence Typing (MLST), we established a Caenorhabditis elegans model to assess C. acnes virulence and we investigated the presence of virulence factors in our collection. Ours results showed that CC36 and CC53 C. acnes isolates were more frequently observed in prosthetic joint infections (PJI) than CC18 and CC28 C. acnes isolates (p = 0.021). The C. elegans model developed here showed two distinct virulence groups of C. acnes (p 
ISSN:1075-9964
1095-8274
DOI:10.1016/j.anaerobe.2017.04.009