Predictive factors for outcomes after reduced intensity conditioning hematopoietic stem cell transplantation for hematological malignancies: a 10-year retrospective analysis from the Société Française de Greffe de Moelle et de Thérapie Cellulaire

This retrospective study analyzed the impact of demographic and transplantation variables on outcomes of 1108 patients who have undergone allogeneic hematopoietic stem cell transplantation after reduced intensity conditioning (RIC HSCT) for hematological malignancies and were reported to the Société...

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Published in:Experimental hematology 2008-05, Vol.36 (5), p.535-544
Main Authors: Michallet, Mauricette, Le, Quoc-Hung, Mohty, Mohamad, Prébet, Thomas, Nicolini, Franck, Boiron, Jean Michel, Esperou, Hélène, Attal, Michel, Milpied, Noel, Lioure, Bruno, Bordigoni, Pierre, Yakoub-Agha, Ibrahim, Bourhis, Jean-Henri, Rio, Bernard, Deconinck, Eric, Renaud, Marc, Chir, Zina, Blaise, Didier
Format: Article
Language:English
Subjects:
Adolescent
Adult
Advanced Basic Science
Aged
Antilymphocyte Serum
Antilymphocyte Serum - administration & dosage
Busulfan
Busulfan - administration & dosage
Child
Child, Preschool
Disease-Free Survival
Female
Follow-Up Studies
France
Graft vs Host Disease
Graft vs Host Disease - diagnosis
Graft vs Host Disease - etiology
Graft vs Host Disease - therapy
Hematologic Neoplasms
Hematologic Neoplasms - diagnosis
Hematologic Neoplasms - therapy
Hematology, Oncology and Palliative Medicine
Hematopoietic Stem Cell Transplantation
Hematopoietic Stem Cell Transplantation - adverse effects
Humans
Immunology
Infant
Life Sciences
Male
Middle Aged
Multivariate Analysis
Predictive Value of Tests
Registries
Remission Induction
Retrospective Studies
Risk Factors
Survival Analysis
Time
Transplantation Conditioning
Transplantation Conditioning - methods
Transplantation, Homologous
Treatment Outcome
Vidarabine
Vidarabine - administration & dosage
Vidarabine - analogs & derivatives
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Summary:This retrospective study analyzed the impact of demographic and transplantation variables on outcomes of 1108 patients who have undergone allogeneic hematopoietic stem cell transplantation after reduced intensity conditioning (RIC HSCT) for hematological malignancies and were reported to the Société Française de Greffe de Moelle et de Thérapie Cellulaire registry between November 1994 and December 2004. Only 442 patients (40%) were in complete remission (CR) at time of transplantation. Peripheral blood stem cells were used in the majority of patients (n = 878; 79%), 255 patients received fludarabine and low-dose total body irradiation, while 465 patients (42%) fludarabine and busulfan with rabbit anti-thymocyte globulins (ATG). The impact of demographic and transplant variables was studied on overall (OS) and event-free survival (EFS) in univariate and multivariate analysis. With a median follow-up of 21 months, 3-year probability of OS and EFS was 42% and 30%, respectively, and treatment-related mortality was 15% at 2 years. The multivariate analysis showed a significant negative impact on OS and EFS of the absence of CR status before transplantation; conditioning regimen, including >10 mg/kg ATG; and minor ABO incompatibility. In conclusion, this study highlights the major impact on RIC HSCT outcome of disease status before transplantation, ATG dose and ABO incompatibility.
ISSN:0301-472X
1873-2399
DOI:10.1016/j.exphem.2008.01.017