A Parturition-Associated Nonsynaptic Coherent Activity Pattern in the Developing Hippocampus

Correlated neuronal activity is instrumental in the formation of networks, but its emergence during maturation is poorly understood. We have used multibeam two-photon calcium microscopy combined with targeted electrophysiological recordings in order to determine the development of population coheren...

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Bibliographic Details
Published in:Neuron (Cambridge, Mass.) Mass.), 2007-04, Vol.54 (1), p.105-120
Main Authors: Crépel, Valérie, Aronov, Dmitriy, Jorquera, Isabel, Represa, Alfonso, Ben-Ari, Yehezkel, Cossart, Rosa
Format: Article
Language:English
Subjects:
Animals
Animals, Newborn
Automation
Calcium
Calcium - metabolism
Calcium Channel Blockers
Calcium Channel Blockers - pharmacology
Cardiotonic Agents
Cardiotonic Agents - pharmacology
Cellular Biology
Electric Stimulation
Electric Stimulation - methods
Embryo, Mammalian
Excitatory Amino Acid Antagonists
Excitatory Amino Acid Antagonists - pharmacology
Gap Junctions
Gap Junctions - drug effects
Gap Junctions - physiology
Gap Junctions - radiation effects
Hippocampus
Hippocampus - cytology
Hippocampus - embryology
Hippocampus - growth & development
In Vitro Techniques
Life Sciences
Membrane Potentials
Membrane Potentials - physiology
Mice
Microscopy
MOLNEURO
Neurons
Neurons - drug effects
Neurons - physiology
Oxytocics
Oxytocics - pharmacology
Oxytocin
Oxytocin - pharmacology
Parturition
Parturition - physiology
Patch-Clamp Techniques
Patch-Clamp Techniques - methods
Population
Potassium
Potassium - pharmacology
Pyrimidines
Pyrimidines - pharmacology
Rodents
Synapses
Synapses - physiology
SYSNEURO
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Description
Summary:Correlated neuronal activity is instrumental in the formation of networks, but its emergence during maturation is poorly understood. We have used multibeam two-photon calcium microscopy combined with targeted electrophysiological recordings in order to determine the development of population coherence from embryonic to postnatal stages in the hippocampus. At embryonic stages (E16–E19), synchronized activity is absent, and neurons are intrinsically active and generate L-type channel-mediated calcium spikes. At birth, small cell assemblies coupled by gap junctions spontaneously generate synchronous nonsynaptic calcium plateaus associated to recurrent burst discharges. The emergence of coherent calcium plateaus at birth is controlled by oxytocin, a maternal hormone initiating labour, and progressively shut down a few days later by the synapse-driven giant depolarizing potentials (GDPs) that synchronize the entire network. Therefore, in the developing hippocampus, delivery is an important signal that triggers the first coherent activity pattern, which is silenced by the emergence of synaptic transmission.
ISSN:0896-6273
1097-4199
DOI:10.1016/j.neuron.2007.03.007