Estimating infra-national and national thyroid cancer incidence in France from cancer registries data and national hospital discharge database

Objective As in many countries, cancer registries cover only part of the population in France. Incidence/mortality ratio observed in registries is usually extrapolated to produce national estimates of cancer incidence. District-level estimates are not currently available. For cancer sites such as th...

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Bibliographic Details
Published in:European journal of epidemiology 2007-09, Vol.22 (9), p.607-614
Main Authors: Uhry, Zoe, Colonna, Marc, Remontet, Laurent, Grosclaude, Pascale, Carré, Nicolas, Couris, Chantal Marie, Velten, Michel
Format: Article
Language:English
Subjects:
Aged
Biological and medical sciences
CANCER
Cancer incidence
Databases, Factual
Endocrinopathies
Epidemiology
Estimating techniques
Female
France
France - epidemiology
General aspects
Hospital admissions
Humans
Interval estimators
Life Sciences
Male
Malignant tumors
Medical records
Medical sciences
Men
Middle Aged
Miscellaneous
Modeling
Mortality
Patient Discharge
Population estimates
Public health. Hygiene
Public health. Hygiene-occupational medicine
Registries
Santé publique et épidémiologie
Surgical specialties
Thyroid cancer
Thyroid gland
Thyroid Neoplasms
Thyroid Neoplasms - epidemiology
Thyroid. Thyroid axis (diseases)
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Summary:Objective As in many countries, cancer registries cover only part of the population in France. Incidence/mortality ratio observed in registries is usually extrapolated to produce national estimates of cancer incidence. District-level estimates are not currently available. For cancer sites such as thyroid, the incidence/mortality ratio widely varies between districts, and alternative indicators must be explored. This study aims to produce national and district-level estimations of thyroid cancer incidence in France, using the ratio between incidence and hospital-based incidence. Methods Analyses concerned population living in France and aged over 20, for the period 1998–2000. For each sex, number of incident cases were analysed according to number of surgery admissions for thyroid cancer (Poisson model) in the districts covered by a registry. Age was included in the model as fixed effect and district as random effect. The model's ability to predict incidence was tested through cross-validation. The model was then extrapolated to produce national incidence estimations, and for women, district-level estimations. Results The national estimations of incidence rate age-standardised on the world population were 3.1 [95% prediction interval: 2.8–3.4] for men and 10.6 [9.8–11.4] for women, corresponding respectively to 1,148 [1,042–1,264] and 4,104 [3,817–4,413] annual new cases. For women, district-level incidence rates presented wide geographical variations, ranging broadly from 5 to 20 per 100,000. These estimations were quite imprecise, but their imprecision was smaller than the extent of geographical disparities. Conclusion National incidence estimations obtained are relatively precise. District-level estimations in women are imprecise and should be treated carefully. They are informative though regarding the extent of geographical disparities. The approach can be useful to improve national incidence estimates and to produce district-level estimates for cancer sites presenting a high variability of the incidence/mortality ratio.
ISSN:0393-2990
1573-7284
DOI:10.1007/s10654-007-9158-6