Maternal alcohol and coffee drinking, parental smoking and childhood leukaemia: a French population-based case-control study

Summary We investigated the role of maternal alcohol and coffee drinking during pregnancy and that of parental smoking in the aetiology of childhood leukaemia. A French, population‐based, case–control study was conducted, comparing 472 [407 acute lymphoblastic leukaemia (ALL) and 62 acute myeloblast...

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Bibliographic Details
Published in:Paediatric and perinatal epidemiology 2007-07, Vol.21 (4), p.293-299
Main Authors: Menegaux, Florence, Ripert, Mahaut, Hémon, Denis, Clavel, Jacqueline
Format: Article
Language:English
Subjects:
Adolescent
Alcohol Drinking - adverse effects
Caffeine - adverse effects
Case-Control Studies
Central Nervous System Stimulants - adverse effects
Child
Child, Preschool
childhood leukaemia
Female
France - epidemiology
Humans
Infant
Leukemia, Myeloid, Acute - epidemiology
Leukemia, Myeloid, Acute - etiology
Life Sciences
Male
maternal alcohol
maternal caffeine
Mothers
parental smoking
Precursor Cell Lymphoblastic Leukemia-Lymphoma - epidemiology
Precursor Cell Lymphoblastic Leukemia-Lymphoma - etiology
Pregnancy
Risk Factors
Santé publique et épidémiologie
Smoking - adverse effects
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Summary:Summary We investigated the role of maternal alcohol and coffee drinking during pregnancy and that of parental smoking in the aetiology of childhood leukaemia. A French, population‐based, case–control study was conducted, comparing 472 [407 acute lymphoblastic leukaemia (ALL) and 62 acute myeloblastic leukaemia] cases of childhood acute leukaemia (AL) and 567 population controls, frequency‐matched with cases on age, gender and region of residence. Both case and control mothers filled in a comprehensive self‐administered standardised questionnaire, eliciting detailed data on maternal alcohol and coffee consumption during pregnancy and parental smoking before, during and after pregnancy. Maternal alcohol consumption of more than 1 drink per day was related to ALL (OR = 2.8 [95% CI 1.8, 5.9]). While maternal coffee consumption was not significantly related to AL (OR = 1.4 [95% CI 0.9, 2.3]), highest intake of coffee (more than 3 cups per day) during pregnancy was associated with AL in children whose mothers were non‐smokers (OR = 1.9 [95% CI 1.0, 3.5]). No association with parental smoking, either maternal or paternal, was observed with AL. The present results suggest a possible role of the highest consumption of alcohol by the mother during pregnancy in the aetiology of childhood AL.
ISSN:0269-5022
1365-3016
DOI:10.1111/j.1365-3016.2007.00824.x