Altered baseline brain activity in children with ADHD revealed by resting-state functional MRI

In children with attention deficit hyperactivity disorder (ADHD), functional neuroimaging studies have revealed abnormalities in various brain regions, including prefrontal-striatal circuit, cerebellum, and brainstem. In the current study, we used a new marker of functional magnetic resonance imagin...

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Bibliographic Details
Published in:Brain & development (Tokyo. 1979) 2007-03, Vol.29 (2), p.83-91
Main Authors: Yu-Feng, Zang, Yong, He, Chao-Zhe, Zhu, Qing-Jiu, Cao, Man-Qiu, Sui, Meng, Liang, Li-Xia, Tian, Tian-Zi, Jiang, Yu-Feng, Wang
Format: Article
Language:English
Subjects:
Adolescent
Amplitude
Attention Deficit Disorder with Hyperactivity - pathology
Attention Deficit Disorder with Hyperactivity - physiopathology
Attention deficit hyperactivity disorder
Brain - blood supply
Brain Mapping
Computer Science
Head Movements - physiology
Humans
Image Processing, Computer-Assisted
Low-frequency fluctuation
Magnetic Resonance Imaging
Male
Medical Imaging
Oxygen - blood
Rest
Resting-state functional MRI
Spontaneous neuronal activity
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Summary:In children with attention deficit hyperactivity disorder (ADHD), functional neuroimaging studies have revealed abnormalities in various brain regions, including prefrontal-striatal circuit, cerebellum, and brainstem. In the current study, we used a new marker of functional magnetic resonance imaging (fMRI), amplitude of low-frequency (0.01–0.08 Hz) fluctuation (ALFF) to investigate the baseline brain function of this disorder. Thirteen boys with ADHD (13.0 ± 1.4 years) were examined by resting-state fMRI and compared with age-matched controls. As a result, we found that patients with ADHD had decreased ALFF in the right inferior frontal cortex, left sensorimotor cortex, and bilateral cerebellum and the vermis as well as increased ALFF in the right anterior cingulated cortex, left sensorimotor cortex, and bilateral brainstem. This resting-state fMRI study suggests that the changed spontaneous neuronal activity of these regions may be implicated in the underlying pathophysiology in children with ADHD.
ISSN:0387-7604
1872-7131
DOI:10.1016/j.braindev.2006.07.002