Persistence and load of high‐risk HPV are predictors for development of high‐grade cervical lesions: A longitudinal French cohort study

Oncogenic HPV types are the major cause of worldwide cervical cancer, but only a small proportion of infected women will develop high‐grade cervical intraepithelial neoplasia or cancer (CIN2/3+). We performed a prospective study including 781 women with normal, atypical squamous cells of undetermine...

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Bibliographic Details
Published in:International journal of cancer 2003-09, Vol.106 (3), p.396-403
Main Authors: Dalstein, Véronique, Riethmuller, Didier, Prétet, Jean‐Luc, Le Bail Carval, Karine, Sautière, Jean‐Loup, Carbillet, Jean‐Pierre, Kantelip, Bernadette, Schaal, Jean‐Patrick, Mougin, Christiane
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Biological and medical sciences
Carcinoma, Squamous Cell - epidemiology
Carcinoma, Squamous Cell - pathology
Carcinoma, Squamous Cell - virology
cervical cancer
cervical intraepithelial neoplasia
Cervical Intraepithelial Neoplasia - epidemiology
Cervical Intraepithelial Neoplasia - pathology
Cervical Intraepithelial Neoplasia - virology
Cervix Uteri - cytology
Cohort Studies
DNA, Viral - genetics
DNA, Viral - metabolism
False Negative Reactions
False Positive Reactions
Female
Female genital diseases
France - epidemiology
Gynecology. Andrology. Obstetrics
high‐grade squamous intraepithelial lesions (HGSIL)
Human papillomavirus
human papillomavirus (HPV)
Humans
Hybrid Capture II
Incidence
Life Sciences
Longitudinal Studies
Medical sciences
Middle Aged
Papillomaviridae - physiology
Papillomavirus Infections - epidemiology
Papillomavirus Infections - pathology
Papillomavirus Infections - virology
Prospective Studies
Risk Factors
Tumor Virus Infections - epidemiology
Tumor Virus Infections - pathology
Tumor Virus Infections - virology
Tumors
Uterine Cervical Neoplasms - epidemiology
Uterine Cervical Neoplasms - pathology
Uterine Cervical Neoplasms - virology
Vaginal Smears
Viral Load
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Summary:Oncogenic HPV types are the major cause of worldwide cervical cancer, but only a small proportion of infected women will develop high‐grade cervical intraepithelial neoplasia or cancer (CIN2/3+). We performed a prospective study including 781 women with normal, atypical squamous cells of undetermined significance (ASCUS) or low‐grade squamous intraepithelial lesion (LGSIL) cytology, and infected or not by high‐risk (HR) HPV tested by Hybrid Capture II. Women were followed up every 6 months for a median period of 22 months. Among the HR‐HPV‐positive women at entry, more than half cleared their virus in 7.5 months; the clearance rate was greater for low viral loads than for high loads and also was higher in women with an initial ASCUS/LGSIL smear than in women with normal cytology. The incidence of cytologic abnormalities strongly depended on baseline viral load and HR‐HPV persistence. Maintenance of cytologic abnormalities was associated with the outcome of HR‐HPV status (negative
ISSN:0020-7136
1097-0215
DOI:10.1002/ijc.11222