Lifetime excess absolute risk for lung cancer due to exposure to radon: results of the pooled uranium miners cohort study PUMA

The Pooled Uranium Miners Analysis (PUMA) study is the largest uranium miners cohort with 119,709 miners, 4.3 million person-years at risk and 7754 lung cancer deaths. Excess relative rate (ERR) estimates for lung cancer mortality per unit of cumulative exposure to radon progeny in working level mon...

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Bibliographic Details
Published in:Radiation and environmental biophysics 2024-03, Vol.63 (1), p.7-16
Main Authors: Kreuzer, M., Sommer, M., Deffner, V., Bertke, S., Demers, P. A., Kelly-Reif, K., Laurier, D., Rage, E., Richardson, D. B., Samet, J. M., Schubauer-Berigan, M. K., Tomasek, L., Wiggins, C., Zablotska, L. B., Fenske, N.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age
Apoptosis Regulatory Proteins
Biological and Medical Physics
Biophysics
Cohort Studies
Ecosystems
Effects of Radiation/Radiation Protection
Environmental Physics
Estimates
Exposure
Humans
Life Sciences
Lung cancer
Lung Neoplasms - epidemiology
Lung Neoplasms - etiology
Middle Aged
Monitoring/Environmental Analysis
Mortality
Neoplasms, Radiation-Induced - epidemiology
Neoplasms, Radiation-Induced - etiology
Occupational Diseases - epidemiology
Occupational Exposure - adverse effects
Physics
Physics and Astronomy
Radon
Radon - adverse effects
Risk
Uranium
Uranium - adverse effects
Young Adult
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Summary:The Pooled Uranium Miners Analysis (PUMA) study is the largest uranium miners cohort with 119,709 miners, 4.3 million person-years at risk and 7754 lung cancer deaths. Excess relative rate (ERR) estimates for lung cancer mortality per unit of cumulative exposure to radon progeny in working level months (WLM) based on the PUMA study have been reported. The ERR/WLM was modified by attained age, time since exposure or age at exposure, and exposure rate. This pattern was found for the full PUMA cohort and the 1960 + sub-cohort, i.e., miners hired in 1960 or later with chronic low radon exposures and exposure rates. The aim of the present paper is to calculate the lifetime excess absolute risk (LEAR) of lung cancer mortality per WLM using the PUMA risk models, as well as risk models derived in previously published smaller uranium miner studies, some of which are included in PUMA. The same methods were applied for all risk models, i.e., relative risk projection up to
ISSN:0301-634X
1432-2099
1432-2099
DOI:10.1007/s00411-023-01049-w