Optimal intertemporal curative drug expenses: The case of hepatitis C in France

We study intertemporal tradeoffs that health authorities face when considering the control of an epidemic using innovative curative medical treatments. We set up a dynamically controlled susceptible–infected–recovered (SIR) model for an epidemic in which patients can be asymptomatic, and we analyze...

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Bibliographic Details
Published in:Journal of health economics 2024-03, Vol.94, p.102861-102861, Article 102861
Main Authors: Dubois, Pierre, Magnac, Thierry
Format: Article
Language:English
Subjects:
Budgets
Controlled epidemic dynamics
Economics and Finance
Epidemics
France - epidemiology
Hepatitis C
Hepatitis C - drug therapy
Hepatitis C - epidemiology
Humanities and Social Sciences
Humans
Life Sciences
Optimal intertemporal policies
Pharmaceuticals
Santé publique et épidémiologie
SIR model
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Summary:We study intertemporal tradeoffs that health authorities face when considering the control of an epidemic using innovative curative medical treatments. We set up a dynamically controlled susceptible–infected–recovered (SIR) model for an epidemic in which patients can be asymptomatic, and we analyze the optimality conditions of the sequence of cure expenses decided by health authorities at the onset of the drug innovation process. We show that analytical conclusions are ambiguous because of their dependence on parameter values. As an application, we focus on the case study of hepatitis C, the treatment for which underwent a major upheaval when curative drugs were introduced in 2014. We calibrate our controlled SIR model using French data and simulate optimal policies. We show that the optimal policy entails some front loading of the intertemporal budget. The analysis demonstrates how beneficial intertemporal budgeting can be compared to non-forward-looking constant budget allocation.
ISSN:0167-6296
1879-1646
DOI:10.1016/j.jhealeco.2024.102861