Recent advances in the chemistry and biology of pyridopyrimidines

The interest in pyridopyrimidine cores for pharmaceutical products makes this scaffold a highly useful building block for organic chemistry. These derivatives have found applications in various areas of medicine such as anticancer, CNS, fungicidal, antiviral, anti-inflammatory, antimicrobial, and an...

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Bibliographic Details
Published in:European journal of medicinal chemistry 2015-05, Vol.95, p.76-95
Main Authors: Buron, F., Mérour, J.Y., Akssira, M., Guillaumet, G., Routier, S.
Format: Article
Language:English
Subjects:
Animals
Anti-Infective Agents - chemistry
Anti-Infective Agents - pharmacology
Anti-Inflammatory Agents - chemistry
Anti-Inflammatory Agents - pharmacology
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Antiviral Agents - chemistry
Antiviral Agents - pharmacology
Central Nervous System Agents - chemistry
Central Nervous System Agents - pharmacology
Chemical Sciences
Drug Design
Heterocycles
Heterocyclic Compounds - chemistry
Heterocyclic Compounds - pharmacology
Humans
Medicinal Chemistry
Organic chemistry
Pharmacological activities
Pyridopyrimidine
Pyrimidines - chemistry
Pyrimidines - pharmacology
Synthesis
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Summary:The interest in pyridopyrimidine cores for pharmaceutical products makes this scaffold a highly useful building block for organic chemistry. These derivatives have found applications in various areas of medicine such as anticancer, CNS, fungicidal, antiviral, anti-inflammatory, antimicrobial, and antibacterial therapies. This review mainly focuses on the progress achieved since 2004 in the chemistry and biological activity of pyridopyrimidines. [Display omitted] •A pyridopyrimidine medicinal chemistry survey.•Access with organic synthesis methods.•Anticancer, anti-inflammatories, CNS and antiviral activities.•Patents exploration.
ISSN:0223-5234
1768-3254
DOI:10.1016/j.ejmech.2015.03.029