Salbutamol intake and substrate oxidation during submaximal exercise

In order to test the hypothesis that salbutamol would change substrate oxidation during submaximal exercise, eight recreationally trained men twice performed 1 h at 60% V O 2 peak after ingestion of placebo or 4 mg of salbutamol. Gas exchange was monitored and blood samples were collected during exe...

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Bibliographic Details
Published in:European journal of applied physiology 2009-01, Vol.105 (2), p.207-213
Main Authors: Arlettaz, A., Le Panse, B., Portier, H., Lecoq, A.-M., Thomasson, R., De Ceaurriz, J., Collomp, K.
Format: Article
Language:English
Subjects:
Adrenocorticotropic Hormone - blood
Albuterol - pharmacology
Asthma
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Blood Glucose
Energy
Exercise
Exercise - physiology
Fundamental and applied biological sciences. Psychology
Glucose
Growth Hormone - blood
Human Physiology
Humans
Insulin - blood
Laboratories
Lactic Acid - blood
Life Sciences
Male
Medical research
Metabolism
Occupational Medicine/Industrial Medicine
Original Article
Oxidation
Oxidation-Reduction - drug effects
Physical Endurance - drug effects
Physical Endurance - physiology
Physical Exertion - drug effects
Physical Exertion - physiology
Physical fitness
Sports Medicine
Time Factors
Vertebrates: body movement. Posture. Locomotion. Flight. Swimming. Physical exercise. Rest. Sports
Young Adult
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Summary:In order to test the hypothesis that salbutamol would change substrate oxidation during submaximal exercise, eight recreationally trained men twice performed 1 h at 60% V O 2 peak after ingestion of placebo or 4 mg of salbutamol. Gas exchange was monitored and blood samples were collected during exercise for GH, ACTH, insulin, and blood glucose and lactate determination. With salbutamol versus placebo, there was no significant difference in total energy expenditure and substrate oxidation, but the substrate oxidation balance was significantly modified after 40 min of exercise. ACTH was significantly decreased with salbutamol during the last 10 min of exercise, whereas no difference was found between the two treatments in the other hormonal and metabolic parameters. The theory that the ergogenic effect of salbutamol results from a change in substrate oxidation has little support during relatively short term endurance exercise, but it is conceivable that longer exercise duration can generate positive findings.
ISSN:1439-6319
1439-6327
DOI:10.1007/s00421-008-0891-7