Penicillium and Talaromyces spp. emerging pathogens in dogs since 1990s

Abstract Penicillium and Talaromyces spp. are environmental saprophytic molds rarely encountered as infectious agents in humans and animals. This article summarizes the clinical features, treatment, and outcomes of proven infections caused by Penicillium or Talaromyces in four dogs in France. Two do...

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Bibliographic Details
Published in:Medical mycology (Oxford) 2023-09, Vol.61 (9)
Main Authors: Monpierre, Lorra, Soetart, Nicolas, Valsecchi, Isabel, Brément, Thomas, Brunelat, Philippe, Drut, Amandine, David, Manon, Roux, Cécile, Hubert, Floriane, Razafimandimby, Bienvenue, Jouvion, Grégory, Miclard, Julien, Chermette, René, Botterel, Françoise, Guillot, Jacques
Format: Article
Language:English
Subjects:
Animal biology
Life Sciences
Veterinary medicine and animal Health
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Summary:Abstract Penicillium and Talaromyces spp. are environmental saprophytic molds rarely encountered as infectious agents in humans and animals. This article summarizes the clinical features, treatment, and outcomes of proven infections caused by Penicillium or Talaromyces in four dogs in France. Two dogs had disseminated infections, while the other two had a localized form. All dogs had positive histopathological results showing the presence of hyaline septate hyphae and a positive fungal culture with typical Penicillium conidiophores. Talaromyces georgiensis (n = 1), Penicillium labradorum (n = 2), and Penicillium from section Ramosa series Raistrickiorum (n = 1), were identified based on Internal Transcribed Spacer (ITS) Sanger sequencing. The dogs were initially treated with ketoconazole or itraconazole. Second-line treatment was initiated in three dogs, but after several relapses, the prognosis remained poor. Since the 1990s, 18 cases of Penicillium or Talaromyces infections in dogs have been described worldwide. This series of four reports brings new cases to those already reported in the literature, which are probably underestimated in the world. Lay Summary Penicillium and Talaromyces spp. are molds found in the environment that rarely cause infections in humans and animals. This article summarizes the clinical features and treatment of proven infections caused by Penicillium or Talaromyces species in four dogs in France.
ISSN:1369-3786
1460-2709
1365-280X
DOI:10.1093/mmy/myad087