Impact of infusion set characteristics on the accuracy of patient‐controlled morphine administration: a controlled in‐vitro study

Summary The aim of our in‐vitro study was to assess the impact of infusion set characteristics on the accuracy of morphine doses in patient‐controlled analgesia. Two infusion sets differing in conception and dead‐space volume were assessed: a standard set and a low dead‐space volume Y‐set. The patie...

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Bibliographic Details
Published in:Anaesthesia 2014-02, Vol.69 (2), p.131-136
Main Authors: Foinard, A., Décaudin, B., Barthélémy, C., Lebuffe, G., Debaene, B., Odou, P.
Format: Article
Language:English
Subjects:
Analgesia, Patient-Controlled - instrumentation
Analgesia, Patient-Controlled - methods
Analgesics, Opioid - administration & dosage
Anesthesia
Drug Administration Schedule
Drug therapy
Equipment Design
Humans
Infusion Pumps
Infusions, Intravenous
Life Sciences
Morphine - administration & dosage
Patients
Reproducibility of Results
Spectrophotometry, Ultraviolet - methods
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Summary:Summary The aim of our in‐vitro study was to assess the impact of infusion set characteristics on the accuracy of morphine doses in patient‐controlled analgesia. Two infusion sets differing in conception and dead‐space volume were assessed: a standard set and a low dead‐space volume Y‐set. The patient‐controlled analgesia programme parameters were as follows: bolus equal to 1 ml at 100 ml.h−1; lockout intervals equal to 5 and 10 min; and carrier fluid flow rate equal to 10 and 50 ml.h−1. Morphine concentration was determined by an ultraviolet spectrophotometric method. The morphine doses were significantly different from one set to the other during bolus and lockout intervals, whatever the patient‐controlled analgesia programme. The average doses were approximately 1.3–6.0 times higher with the low dead‐space volume Y‐set during bolus. Our study underlines the impact of infusion set characteristics on the accuracy of morphine patient‐controlled analgesia doses.
ISSN:0003-2409
1365-2044
DOI:10.1111/anae.12523