host model Galleria mellonella is resistant to taylorellae infection

The genus Taylorella is composed of two species: (i) Taylorella equigenitalis, the causative agent of CEM, a venereally transmitted infection of Equidae and (ii) Taylorella asinigenitalis, a closely related species considered to be nonpathogenic, although experimental infection of mares with this ba...

Full description

Saved in:
Bibliographic Details
Published in:Letters in applied microbiology 2014-10, Vol.59 (4), p.438-442
Main Authors: Hébert, L, Rincé, I, Sanna, C, Laugier, C, Rincé, A, Petry, S
Format: Article
Language:English
Subjects:
Animals
bacteria
Bacteriological Techniques
Biological and medical sciences
contagious equine metritis
endometritis
Equidae
Fundamental and applied biological sciences. Psychology
Galleria mellonella
Gram-Negative Bacterial Infections - microbiology
hosts
infection model
Larva - microbiology
larvae
Life Sciences
mares
Microbiology
mortality
Moths - microbiology
Taylorella asinigenitalis
Taylorella equigenitalis
Taylorella equigenitalis - physiology
vaginitis
virulence
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The genus Taylorella is composed of two species: (i) Taylorella equigenitalis, the causative agent of CEM, a venereally transmitted infection of Equidae and (ii) Taylorella asinigenitalis, a closely related species considered to be nonpathogenic, although experimental infection of mares with this bacterium resulted in clinical signs of vaginitis, cervicitis or endometritis. Currently, there is a need for an alternative host model to further study the taylorellae species. In this context, we explored Galleria mellonella larvae as potential alternative model hosts for taylorellae. Our results showed that infection of G. mellonella larvae with a high concentration of taylorellae did not induce overt G. mellonella mortality and that taylorellae were not able to proliferate within G. mellonella. In conclusion, G. mellonella larvae are resistant to taylorellae infection and therefore do not constitute a relevant alternative system for studying the virulence of taylorellae species. SIGNIFICANCE AND IMPACT OF THE STUDY: To date, the pathogenicity and host colonization capacity of Taylorella equigenitalis, the causative agent of contagious equine metritis (CEM) and T. asinigenitalis, the second species within the Taylorella genus, remain largely unknown. In this study, we evaluated the relevance of Galleria mellonella as an infection model for taylorellae; we showed that G. mellonella are resistant to taylorellae infection and therefore do not constitute a suitable host model for taylorellae.
ISSN:0266-8254
1472-765X
DOI:10.1111/lam.12297