Saliva DHEA and cortisol responses following short-term corticosteroid intake

Eur J Clin Invest 2010; 40 (2): 183–186 Background  Given the high correlation between the serum and saliva hormone values demonstrated at rest, saliva provides a convenient non‐invasive way to determine dehydroepiandrosterone (DHEA) and cortisol concentrations. However, to our knowledge, pituitary...

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Published in:European journal of clinical investigation 2010-02, Vol.40 (2), p.183-186
Main Authors: Jollin, L., Thomasson, R., Le Panse, B., Baillot, A., Vibarel-Rebot, N., Lecoq, A. M., Amiot, V., De Ceaurriz, J., Collomp, K.
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Dehydroepiandrosterone - metabolism
Enzyme-Linked Immunosorbent Assay
Female
General aspects
Glucocorticoids - administration & dosage
Humans
Hydrocortisone - metabolism
Hypothalamic-pituitary-adrenal axis
Life Sciences
Medical sciences
Metabolic diseases
prednisone
Prednisone - administration & dosage
recovery
Saliva - metabolism
saliva samples
Young Adult
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Summary:Eur J Clin Invest 2010; 40 (2): 183–186 Background  Given the high correlation between the serum and saliva hormone values demonstrated at rest, saliva provides a convenient non‐invasive way to determine dehydroepiandrosterone (DHEA) and cortisol concentrations. However, to our knowledge, pituitary adrenal recovery following short‐term suppression with corticosteroids has never been investigated in saliva. The aim of this study was therefore to examine how steroid hormone concentrations in saliva are influenced by short‐term corticosteroid administration. Materials and methods  We studied saliva DHEA and cortisol concentrations before, during (day 1–day 7) and following (day 8–day 16) the administration of oral therapeutic doses of prednisone (50 mg daily for 1 week) in 11 healthy recreationally trained women. Results  Mean saliva DHEA and cortisol concentrations decreased immediately after the start of prednisone treatment (P 
ISSN:0014-2972
1365-2362
DOI:10.1111/j.1365-2362.2009.02219.x