Association Between Use of Anticancer Drugs and Cardiovascular Disease–Related Hospitalization in Metastatic Colorectal Cancer: Insights From a Population-Based Study, the Anticancer Vigilance of Cardiac Events Study

Abstract We aimed to investigate the association between use of anticancer drugs and cardiovascular-related hospitalization (CVRH) among patients with metastatic colorectal cancer (mCRC). A cohort study, the Anticancer Vigilance of Cardiac Events (AVOCETTE) Study, was conducted using data from the d...

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Bibliographic Details
Published in:American journal of epidemiology 2021-03, Vol.190 (3), p.376-385
Main Authors: Dolladille, Charles, Launoy, Guy, Bouvier, Véronique, Salem, Joe-Elie, Legallois, Damien, Milliez, Paul, Sassier, Marion, Lobbedez, Thierry, Guittet, Lydia, Alexandre, Joachim
Format: Article
Language:English
Subjects:
5-Fluorouracil
Age Factors
Aged
Aged, 80 and over
Antineoplastic Agents - administration & dosage
Antineoplastic Agents - adverse effects
Antineoplastic Agents - therapeutic use
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Antineoplastic drugs
Antitumor agents
Bevacizumab
Cancer
Cardiovascular diseases
Cardiovascular Diseases - epidemiology
Colorectal cancer
Colorectal carcinoma
Colorectal Neoplasms - drug therapy
Colorectal Neoplasms - mortality
Colorectal Neoplasms - pathology
Comorbidity
Confidence intervals
Drugs
Female
Heart
Hospitalization - statistics & numerical data
Humans
Irinotecan
Life Sciences
Male
Metastases
Metastasis
Middle Aged
Neoplasm Metastasis
Oxaliplatin
Patients
Population studies
Population-based studies
Retrospective Studies
Sex Factors
Statistical analysis
Statistical tests
Vigilance
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Summary:Abstract We aimed to investigate the association between use of anticancer drugs and cardiovascular-related hospitalization (CVRH) among patients with metastatic colorectal cancer (mCRC). A cohort study, the Anticancer Vigilance of Cardiac Events (AVOCETTE) Study, was conducted using data from the digestive tumor registry of a French county, the Département du Calvados. Incident mCRC cases diagnosed between 2008 and 2014 were included. The follow-up end date was December 31, 2016. Data from the county hospital center pharmacy and medical information departments were matched with the registry data. A competing-risks approach was used. Statistical tests were 2-sided. A total of 1,116 mCRC patients were included, and they were administered 12,374 rounds of treatment; fluorouracil, oxaliplatin, irinotecan, and bevacizumab were most common drugs used. A total of 208 CVRH events occurred in 145 patients (13.0%). The International Cancer Survival Standards type 1 standardized incidence was 84.0 CVRH per 1,000 person-years (95% confidence interval: 72.6, 95.5). Anticancer drugs were not associated with a higher incidence of CVRH. Male sex, increasing age, a prior history of CVRH, and a higher Charlson comorbidity index score were associated with a higher incidence of CVRH. CVRH was significantly associated with higher all-cause mortality (multivariable hazard ratio = 1.58, 95% confidence interval: 1.28, 1.95). In this study, anticancer drugs were not associated with a higher incidence of CVRH in mCRC patients.
ISSN:0002-9262
1476-6256
DOI:10.1093/aje/kwaa203