Oxidative stress, HDL functionality and effects of intravenous iron administration in women with iron deficiency anemia

Summary Background and aims Iron deficiency anemia (IDA) affects around 20–30% of adults worldwide. An association between IDA and cardiovascular disease (CVD) has been reported. Oxidative stress, inflammation and low concentration of high-density lipoproteins (HDL) were implicated on endothelial dy...

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Bibliographic Details
Published in:Clinical nutrition (Edinburgh, Scotland) Scotland), 2017-04, Vol.36 (2), p.552-558
Main Authors: Meroño, Tomás, Dauteuille, Carolane, Tetzlaff, Walter, Martín, Maximiliano, Botta, Eliana, Lhomme, Marie, Saez, María Soledad, Sorroche, Patricia, Boero, Laura, Arbelbide, Jorge, Chapman, M. John, Kontush, Anatol, Brites, Fernando
Format: Article
Language:English
Subjects:
Administration, Intravenous
Adult
Anemia, Iron-Deficiency - blood
Anemia, Iron-Deficiency - drug therapy
Aryldialkylphosphatase - blood
Carboxylic Ester Hydrolases - blood
Case-Control Studies
Cholesterol Ester Transfer Proteins - blood
Cholesterol, HDL - blood
Cholesterol, LDL - blood
Female
Follow-Up Studies
Gastroenterology and Hepatology
HDL
Humans
Iron
Iron - administration & dosage
Iron - blood
Iron deficiency anemia
Life Sciences
Lipoproteins
Malondialdehyde - blood
Middle Aged
Oxidative stress
Oxidative Stress - drug effects
Paraoxonase
Triglycerides - blood
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Summary:Summary Background and aims Iron deficiency anemia (IDA) affects around 20–30% of adults worldwide. An association between IDA and cardiovascular disease (CVD) has been reported. Oxidative stress, inflammation and low concentration of high-density lipoproteins (HDL) were implicated on endothelial dysfunction and CVD in IDA. We studied the effects of iron deficiency and of an intravenous iron administration on oxidative stress and HDL characteristics in IDA women. Methods Two studies in IDA women are presented: a case–control study, including 18 patients and 18 age-matched healthy women, and a follow-up study 72hr after the administration of intravenous iron (n = 16). Lipids, malondialdehyde, cholesteryl ester transfer protein (CETP), paraoxonase-1 (PON-1) and HDL chemical composition and functionality (cholesterol efflux and antioxidative activity) were measured. Cell cholesterol efflux from iron-deficient macrophages to a reference HDL was also evaluated. Results IDA patients showed higher triglycerides and CETP activity and lower HDL-C than controls (all p 
ISSN:0261-5614
1532-1983
DOI:10.1016/j.clnu.2016.02.003