C-reactive protein values after surgery for inflammatory bowel disease: is it still a good marker for intra-abdominal complication? A retrospective cohort study of 347 procedures

Purpose C-reactive protein (CRP) is a useful predictive test to early detect abdominal complication after colorectal surgery. Inflammatory bowel disease (IBD) is responsible for chronic inflammation and abnormal basal CRP that could influence the interest of its management after abdominal surgery. T...

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Bibliographic Details
Published in:International journal of colorectal disease 2022-11, Vol.37 (11), p.2347-2356
Main Authors: Bouteloup, Gaspard, Lefevre, Jérémie H, Challine, Alexandre, Voron, Thibault, O'Connell, Lauren, Debove, Clotilde, Chafai, Najim
Format: Article
Language:English
Subjects:
Abdomen
Anastomosis
Anastomotic leak
C-reactive protein
Cohort analysis
Complications
Complications and side effects
Inflammation
Inflammatory bowel disease
Inflammatory bowel diseases
Intestine
Life Sciences
Medical research
Medicine, Experimental
Multivariate analysis
Patients
Population studies
Postoperative
Surgery
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Summary:Purpose C-reactive protein (CRP) is a useful predictive test to early detect abdominal complication after colorectal surgery. Inflammatory bowel disease (IBD) is responsible for chronic inflammation and abnormal basal CRP that could influence the interest of its management after abdominal surgery. The aim of this study is to evaluate CRP as an indicator of postoperative complication in a specific IBD population. Methods Retrospective study of patients undergoing ileocolic resection or ileal pouch-anal anastomosis for IBD between 2012 and 2019. Results Ileocolic resection represents 242 patients and ileal pouch-anal anastomosis 105 patients. CRP was significantly higher at an early (105.2 ± 56.0 vs 128.1 ± 69.8; p = 0.008) and late stage (112.9 ± 72.8 vs 185.3 ± 111.5; p 25 kg/m.sup.2 (p = 0.04) and an open surgical approach (p = 0.009) were associated with higher CRP levels in the first postoperative days (POD). In multivariate analysis, preoperative steroid use (p = 0.06), CRP at POD 3 > 100 mg/L (p = 0.003), and a rise between CRP values (p = 0.007) at 48 h were significantly associated with intra-abdominal complication. A CRP at POD 1 < 75 mg/L was associated with a lower rate of intra-abdominal complication (p = 0.01). A score dividing patients into 3 groups according to these values showed significant differences in intra-abdominal complication and anastomotic leakage rates. Conclusion CRP is a useful predictive marker to detect abdominal complication after surgery in IBD population. Measurement of CRP can help to reduce hospitalization stay and orientate towards complementary examinations.
ISSN:0179-1958
1432-1262
DOI:10.1007/s00384-022-04259-8