Influence of the mechanical and geometrical parameters on the cellular uptake of nanoparticles: A stochastic approach

Nanoparticles (NPs) are used for drug delivery with enhanced selectivity and reduced side‐effect toxicity in cancer treatments. Based on the literature, the influence of the NPs mechanical and geometrical properties on their cellular uptake has been studied through experimental investigations. Howev...

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Bibliographic Details
Published in:International journal for numerical methods in biomedical engineering 2022-06, Vol.38 (6), p.e3598-n/a
Main Authors: Iaquinta, Sarah, Khazaie, Shahram, Ishow, Éléna, Blanquart, Christophe, Fréour, Sylvain, Jacquemin, Frédéric
Format: Article
Language:English
Subjects:
Adhesion
Aspect ratio
Biological Transport
Biomechanics
Cell Membrane
Cell membranes
cellular uptake
Complex systems
Drug delivery
Internalization
Mathematical models
Mathematics
Mechanical engineering
mechanical properties
Mechanics
Nanoparticles
Parameters
Physics
Probability
Selectivity
sensitivity analysis
shape
Stochasticity
surrogate modeling
Toxicity
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Summary:Nanoparticles (NPs) are used for drug delivery with enhanced selectivity and reduced side‐effect toxicity in cancer treatments. Based on the literature, the influence of the NPs mechanical and geometrical properties on their cellular uptake has been studied through experimental investigations. However, due to the difficulty to vary the parameters independently in such a complex system, it remains hard to efficiently conclude on the influence of each one of them on the cellular internalization of a NP. In this context, different mechanical / mathematical models for the cellular uptake of NPs have been developed. In this paper, we numerically investigate the influence of the NP's aspect ratio, the membrane tension and the cell‐NP adhesion on the uptake of the NP using the model introduced in1 coupled with a numerical stochastic scheme to measure the weight of each one of the aforementioned parameters. The results reveal that the aspect ratio of the particle is the most influential parameter on the wrapping of the particle by the cell membrane. Then the adhesion contributes twice as much as the membrane tension. Our numerical results match the previous experimental observations. In this work we investigate the influence of the mechanical and geometrical properties of a nanoparticle on its cell uptake. Thus, a sensitivity analysis is performed on a model at the nanoparticle's scale. The study showed that the nanoparticle's aspect ratio is the most important parameter, followed by the cell‐nanoparticle adhesion and the cell membrane tension.
ISSN:2040-7939
2040-7947
DOI:10.1002/cnm.3598