Invasive pneumococcal infections in France: Changes from 2009 to 2021 in antibiotic resistance and serotype distribution of Streptococcus pneumoniae based on data from the French Regional Pneumococcal Observatories network

•Streptococcus pneumoniae infections are frequent and mostly community-based.•In France, the pneumococcal surveillance is monitored by the network of ORP, in collaboration with the National Reference Center•The proportion of PDSP isolated in meningitis increased both in children (29.2, 2009 vs 51.4%...

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Published in:Infectious diseases now (Online) 2023-02, Vol.53 (1), p.104632-104632, Article 104632
Main Authors: Plainvert, C., Varon, E., Viriot, D., Kempf, M., Alauzet, C., Auger, G., Batah, J., Brieu, N., Cattoir, V., Cremniter, J., Culeux, C., Decousser, J.W., El Mniai, A., Goulard de Curraize, C., Gravet, A., Grelaud, C., Hamdad, F., Isnard, C., Labrunie, A., Lanotte, P., Laurens, C., Luce, S., Lemaitre, N., Patry, I., Pelloux, I., Peuchant, O., Ploy, M.C., Revillet, H., Robin, F., Ruimy, R., Vernet-Garnier, V., Wallet, F., Lévy-Bruhl, D., Danis, K.
Format: Article
Language:English
Subjects:
Adult
Amoxicillin - pharmacology
Amoxicillin - therapeutic use
Anti-Bacterial Agents - pharmacology
Anti-Bacterial Agents - therapeutic use
Antimicrobial resistance
Cefotaxime - pharmacology
Cefotaxime - therapeutic use
Child
Drug Resistance, Microbial
France - epidemiology
French Regional Pneumococcal Observatories
Human health and pathology
Humans
Invasive infection
Life Sciences
Penicillins
Pneumococcal Infections - drug therapy
Pneumococcal Infections - epidemiology
Serogroup
Serotype
Streptococcus pneumoniae
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Summary:•Streptococcus pneumoniae infections are frequent and mostly community-based.•In France, the pneumococcal surveillance is monitored by the network of ORP, in collaboration with the National Reference Center•The proportion of PDSP isolated in meningitis increased both in children (29.2, 2009 vs 51.4% in 2021) and in adults (26.1 in 2009 vs 46.1% in 2021)•Most of the serotypes included in the PCV13 have disappeared after vaccine introduction, while those not included in the PCV13 vaccine have emerged The 23 French Regional Pneumococcal Observatories (ORPs) analyzed antibiotic resistance and serotypes of Streptococcus pneumoniae strains isolated from invasive infections in France over a 12-year period. Between 2009 and 2021, the ORPs analyzed 19,319 strains, including 1,965 in children and 17,354 in adults. Strains were assessed for their resistance to penicillin G, amoxicillin and cefotaxime. Serotypes were identified in collaboration with the National Reference Centre. During this period, the number of strains collected yearly decreased significantly. The decrease was particularly pronounced up until 2013, especially in children (-61.0%). However, penicillin non-susceptible strains (PNSPs) increased in children (24.7% in 2009 vs 45.0% in 2021, p 
ISSN:2666-9919
2666-9919
DOI:10.1016/j.idnow.2022.11.001