Intestinal Epithelial-Mesenchymal Cell Interactions

Intestinal morphogenesis, as well as maintenance of the stem cell population and of the steady state between cell proliferation and differentiation, results from controlled cell interactions. There is growing evidence that the mesenchymal cells control epithelial cell behavior via their own expressi...

Full description

Saved in:
Bibliographic Details
Published in:Annals of the New York Academy of Sciences 1998-11, Vol.859 (1), p.1-17
Main Authors: KEDINGER, M., DULUC, I., FRITSCH, C., LORENTZ, O., PLATEROTI, M., FREUND, J. N.
Format: Article
Language:English
Subjects:
Animals
Cell Communication
Cell Differentiation
Cell Division
Cellular Biology
Cytokines - physiology
Gene Expression Regulation, Developmental
Humans
Intestinal Mucosa - embryology
Intestinal Mucosa - physiology
Life Sciences
Mesoderm - physiology
Models, Biological
Morphogenesis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Intestinal morphogenesis, as well as maintenance of the stem cell population and of the steady state between cell proliferation and differentiation, results from controlled cell interactions. There is growing evidence that the mesenchymal cells control epithelial cell behavior via their own expression and induction in the epithelial cells of key regulatory genes. This heterologous cross talk involves basement membrane molecules and paracrine factors. New in vitro/in vivo cellular models allowed us to analyze various mesenchymal cell phenotypes and to show that they exhibit different inductive properties on epithelial cells and that their proliferation and metabolic properties are differentially modulated by cytokines. Finally the epithelial‐mesenchymal unit is controlled by hormonal and exogenous factors.
ISSN:0077-8923
1749-6632
DOI:10.1111/j.1749-6632.1998.tb11107.x