A pharmacological strategy to recapitulate exercise-induced antitumoral immunity

The antitumor activity of exercise by means of enhanced immune activation is documented, but better identification of the underlying mechanisms is required to develop new therapeutic strategies. Recent work from the Dr Bar-Sagi group reveals that exercise engages IL-15 signaling and pharmacological...

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Bibliographic Details
Published in:Trends in pharmacological sciences (Regular ed.) 2022-12, Vol.43 (12), p.1001-1003
Main Authors: Rébillard, Amélie, Nunès, Jacques A, Carrier, Alice
Format: Article
Language:English
Subjects:
Humans
Interleukin-15
Life Sciences
Signal Transduction
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Summary:The antitumor activity of exercise by means of enhanced immune activation is documented, but better identification of the underlying mechanisms is required to develop new therapeutic strategies. Recent work from the Dr Bar-Sagi group reveals that exercise engages IL-15 signaling and pharmacological activation of the IL-15/IL-15R axis mimics the exercise-driven immune cell-mediated cytotoxicity in pancreatic cancer.
ISSN:0165-6147
1873-3735
DOI:10.1016/j.tips.2022.08.004