Seasonal variations in childhood leukaemia incidence in France, 1990–2014

Background Several studies have addressed the potential seasonality of childhood acute leukaemia (AL) without conclusive results. Using data from the National Registry of Childhood Cancers over 1990–2014 in mainland France, we investigated the seasonal variations in childhood AL taken together, and...

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Bibliographic Details
Published in:Cancer causes & control 2021-07, Vol.32 (7), p.693-704
Main Authors: Bamouni, Sophie, Hémon, Denis, Faure, Laure, Clavel, Jacqueline, Goujon, Stéphanie
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Biomedicine
Birth
Cancer
Cancer Research
Children
Diagnosis
Epidemiology
Hematology
Human health and pathology
Leukemia
Life Sciences
Oncology
Original Paper
Pediatrics
Public Health
Santé publique et épidémiologie
Seasonal variations
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Summary:Background Several studies have addressed the potential seasonality of childhood acute leukaemia (AL) without conclusive results. Using data from the National Registry of Childhood Cancers over 1990–2014 in mainland France, we investigated the seasonal variations in childhood AL taken together, and lymphoblastic (ALL) and myeloid (AML) leukaemia separately. Methods Assuming constant variations over 1990–2014, we used a Poisson regression model to evaluate variations in standardized incidence ratios (SIRs) by month of birth or diagnosis. A scan method for temporal cluster detection was used to identify windows of several consecutive months with high or low SIR. The yearly reproducibility of the observed monthly variations was then evaluated. Results We included 11,528 AL, of which 9493 ALL and 1,843 AML. No seasonal variation was detected for ALL. With a clear seasonal pattern, differences in AML incidence rates were evidenced between January–April and May–December birth periods (SIR = 0.85, 95% CI 0.77–0.94 and SIR = 1.07, 95% CI 1.01–1.14, respectively). AML incidence variations by month of diagnosis were less clear-cut. Conclusion Based on a large number of cases from a high-quality registry, we did not evidence any seasonality in ALL incidence rates but evidenced seasonal variations in AML incidence rates by month of birth.
ISSN:0957-5243
1573-7225
DOI:10.1007/s10552-021-01421-5