Visualizing the cerebral distribution of chemical elements: A challenge met with LIBS elemental imaging

Biological tissues contain various metals and metalloids ions with central role in the regulation of several pathophysiological functions. In parallel, the development and the evaluation of novel nanocompounds for biomedicine require the monitoring of their biodistribution in tissues of interest. Th...

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Bibliographic Details
Published in:Journal of neuroscience methods 2022-09, Vol.379, p.109676-109676, Article 109676
Main Authors: Busser, Benoit, Bulin, Anne-Laure, Gardette, Vincent, Elleaume, Hélène, Pelascini, Frédéric, Bouron, Alexandre, Motto-Ros, Vincent, Sancey, Lucie
Format: Article
Language:English
Subjects:
Brain tissue
Elemental imaging
Endogenous elements
Laser-induced breakdown spectroscopy
Life Sciences
Nanoparticles
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Summary:Biological tissues contain various metals and metalloids ions with central role in the regulation of several pathophysiological functions. In parallel, the development and the evaluation of novel nanocompounds for biomedicine require the monitoring of their biodistribution in tissues of interest. Therefore, researchers need to use reliable and accessible techniques to detect and quantify major and trace elements in space-resolved manner. In this communication, we report how Laser-Induced Breakdown Spectroscopy (LIBS) can be used to image the distribution of chemical elements in brain tissues.
ISSN:0165-0270
1872-678X
DOI:10.1016/j.jneumeth.2022.109676