Impact of malignancy on outcomes in European patients with atrial fibrillation: A report from the ESC‐EHRA EURObservational research programme in atrial fibrillation general long‐term registry

Background The management of patients with atrial fibrillation (AF) and malignancy is challenging given the paucity of evidence supporting their appropriate clinical management. Purpose To evaluate the outcomes of patients with active or prior malignancy in a contemporary cohort of European AF patie...

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Published in:European journal of clinical investigation 2022-07, Vol.52 (7), p.e13773-n/a
Main Authors: Malavasi, Vincenzo L., Potpara, Tatjana S., Kalarus, Zbigniew, Lane, Deirdre A., Goda, A, García Bolao, I, Poposka, L, Erküner, Ö, Lenarczyk, R, Shah, D, Massoz, M, Bakalska‐Georgieva, S, Slavcheva, S, Vester, S, Poulard, J, Furber, A, Roubille, F, Le Heuzey, J, Chastre, T, Arnaud, D, Boury, F, Haissaguerre, M, Lozance, N, Jovevska, S, Lazarova, E, Sagirashvili, E, Kuridze, N, Papiashvili, G, Boscher, D, Wilhelm, K, Anneken, L, Klaus, C, Kaul, N, Mutscher, I, Gerth, A, Degenhardt, R, Bernucci, D, Frisoni, J, Abela, E, Vukmirovic, M, Es, J, Crijns, H, Janse, P, Koba, E, Kowalik‐Sztylc, A, Winiarska‐Filipek, A, Slowikowski, A, Stasiak, M, Prasał, M, Feusette, P, Zakrzewski, M, Skorek, E, Szabowski, S, Michalczyk, L, Skrobowski, A, Balsam, P, Wancerz, A, Jedrzejczyk‐Patej, E, Szpot, M, Almeida, S, Peres, M, Frunza, S, Toma, N, Patrascu, N, Stoicescu, C, Vinereanu, D, Cinteza, M, Corina, A, Vacarescu, C, Pescariu, S, Soldatova, I, Arandjelovic, A, Vujisic‐Tesic, B, Nedeljkovic, M, Simovic, S, Davidovic, G, Mau, E, Tello Montoliu, A, Veliz Martínez, A, Gagirci, G, Taha Alper, A, Demir, M, Stancombe, L, Senoo, K, Whiteside, C, McKie, H, Holland, M, Ahmad, S, McKinley, S, Sobolewska, J, Ndlovu, N, Stockport, J, Tivenan, H, Jhagra, O, Beveridge, M, Mills, H, Walker, E, Saunders, G, Jones, R
Format: Article
Language:English
Subjects:
all‐cause death
Anticoagulants
atrial fibrillation
Atrial Fibrillation - complications
Bleeding
cancer
Cardiac arrhythmia
Death
Fibrillation
Hemorrhage
Hemorrhage - chemically induced
Hemorrhage - epidemiology
Humanities and Social Sciences
Humans
Malignancy
Mortality
Neoplasms - drug therapy
NOACs
Patients
Registries
registry
Risk
Risk Factors
Stroke - complications
Stroke - epidemiology
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Summary:Background The management of patients with atrial fibrillation (AF) and malignancy is challenging given the paucity of evidence supporting their appropriate clinical management. Purpose To evaluate the outcomes of patients with active or prior malignancy in a contemporary cohort of European AF patients. Methods Patients enrolled in the EURObservational Research Programme in AF General Long‐Term Registry were categorized into 3 categories: No Malignancy (NoMal), Prior Malignancy (PriorMal) and Active Malignancy (ActiveMal). The primary outcomes were all‐cause death and the composite outcome MACE. Results A total of 10 383 patients were analysed. Of these, 9597 (92.4%) were NoMal patients, 577 (5.6%) PriorMal and 209 (2%) ActiveMal. Lack of any antithrombotic treatment was more prevalent in ActiveMal patients (12.4%) as compared to other groups (5.0% vs 6.3% for PriorMal and NoMal, p 
ISSN:0014-2972
1365-2362
DOI:10.1111/eci.13773