Consensus statement by the French Society of Endocrinology (SFE) and French Society of Pediatric Endocrinology & Diabetology (SFEDP) on diagnosis of Cushing's syndrome

Cushing's syndrome is defined by prolonged exposure to glucocorticoids, leading to excess morbidity and mortality. Diagnosis of this rare pathology is difficult due to the low specificity of the clinical signs, the variable severity of the clinical presentation, and the difficulties of interpre...

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Published in:Annales d'endocrinologie 2022-04, Vol.83 (2), p.119-141
Main Authors: Tabarin, Antoine, Assié, Guillaume, Barat, Pascal, Bonnet, Fidéline, Bonneville, Jean François, Borson-Chazot, Françoise, Bouligand, Jérôme, Boulin, Anne, Brue, Thierry, Caron, Philippe, Castinetti, Frédéric, Chabre, Olivier, Chanson, Philippe, Corcuff, Jean Benoit, Cortet, Christine, Coutant, Régis, Dohan, Anthony, Drui, Delphine, Espiard, Stéphanie, Gaye, Delphine, Grunenwald, Solenge, Guignat, Laurence, Hindie, Elif, Illouz, Frédéric, Kamenicky, Peter, Lefebvre, Hervé, Linglart, Agnès, Martinerie, Laetitia, North, Marie Odile, Raffin-Samson, Marie Laure, Raingeard, Isabelle, Raverot, Gérald, Raverot, Véronique, Reznik, Yves, Taieb, David, Vezzosi, Delphine, Young, Jacques, Bertherat, Jérôme
Format: Article
Language:English
Subjects:
ACTH
Cushing's disease
Cushing's syndrome
Genetic
Hypercortisolism
Life Sciences
Pregnancy
Santé publique et épidémiologie
Suppression
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Summary:Cushing's syndrome is defined by prolonged exposure to glucocorticoids, leading to excess morbidity and mortality. Diagnosis of this rare pathology is difficult due to the low specificity of the clinical signs, the variable severity of the clinical presentation, and the difficulties of interpretation associated with the diagnostic methods. The present consensus paper by 38 experts of the French Society of Endocrinology and the French Society of Pediatric Endocrinology and Diabetology aimed firstly to detail the circumstances suggesting diagnosis and the biologic diagnosis tools and their interpretation for positive diagnosis and for etiologic diagnosis according to ACTH-independent and -dependent mechanisms. Secondly, situations making diagnosis complex (pregnancy, intense hypercortisolism, fluctuating Cushing's syndrome, pediatric forms and genetically determined forms) were detailed. Lastly, methods of surveillance and diagnosis of recurrence were dealt with in the final section.
ISSN:0003-4266
2213-3941
DOI:10.1016/j.ando.2022.02.001