The evaluation of cosmetic and pharmaceutical emulsions aging process using classical techniques and a new method: FTIR

The purpose of this paper is to show how the utilization of Fourier Transform Infrared (FTIR) spectroscopy can be interesting in stability studying of cosmetic or pharmaceutical “oil in water” (O/W) emulsions. In this study temperature storage tests were performed to accelerate the aging process and...

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Bibliographic Details
Published in:International journal of pharmaceutics 2005-01, Vol.289 (1), p.117-131
Main Authors: Masmoudi, H., Dréau, Y. Le, Piccerelle, P., Kister, J.
Format: Article
Language:English
Subjects:
Aging
Analytical chemistry
Biological and medical sciences
Chemical Sciences
Conductivity
Cosmetics - chemistry
Cosmetics - standards
Deconvolution
Dosage Forms
Drug Evaluation, Preclinical - methods
Drug Evaluation, Preclinical - trends
Drug Stability
Emulsion
Emulsions - chemistry
Emulsions - standards
FTIR
General pharmacology
Life Sciences
Medical sciences
Other
Oxidation
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Spectroscopy, Fourier Transform Infrared - methods
Spectroscopy, Fourier Transform Infrared - trends
Temperature
Thermal Conductivity
Time Factors
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Summary:The purpose of this paper is to show how the utilization of Fourier Transform Infrared (FTIR) spectroscopy can be interesting in stability studying of cosmetic or pharmaceutical “oil in water” (O/W) emulsions. In this study temperature storage tests were performed to accelerate the aging process and evaluate the stability of five emulsions. Emulsions were analyzed by FTIR and classical methods (conductivity, viscosity, pH, texture analysis) in order to determine a method that would enable predicting the emulsion's stability. During the aging process, modifications of chemical functions are measured by FTIR (using spectrometric indices), such modifications included: a decrease of unsaturation index, an increase of carbonyl index and a broadening of the carbonyl band. This band was deconvoluted to evaluate the contribution of different species in the broadening phenomenon, which seems to be caused by the appearance of free fatty acids. Conductimetry seems to be the most sensitive technique to assess physical modifications during emulsion's aging. Concerning the most unstable emulsions, a progressive increasing of conductivity was observed several months before the emulsion destabilizes. Consequently, FTIR and conductimetry are two complementary techniques. Conductimetry is a useful technique to predict emulsion destabilization while FTIR allows the measurement of chemical modifications and helps to understand the chemical mechanisms which occur during the oxidation.
ISSN:0378-5173
1873-3476
DOI:10.1016/j.ijpharm.2004.10.020