Characterization of the conglomerate form of acetyl-dl-leucine by thermal analysis and solubility measurements

Starting from a mixture of enantiomers in solution, crystallization can generate different types of crystals. In order to determine which type of crystal is obtained in the case of acetyl leucine, an active pharmaceutical ingredient (API), analytical methods have been used to partially elucidate the...

Full description

Saved in:
Bibliographic Details
Published in:Journal of crystal growth 2012-03, Vol.342 (1), p.28-33
Main Authors: Estime, N., Pena, R., Teychené, S., Autret, J.M., Biscans, B.
Format: Article
Language:English
Subjects:
A1. Conglomerate
A1. Phase diagram
A1. Racemic
A2. Crystallization
B1. Acetyl leucine
Binary systems
Chemical engineering
Chemical Sciences
Condensed matter: structure, mechanical and thermal properties
Cristallography
Crystalline state (including molecular motions in solids)
Crystallization
Crystallographic aspects of phase transformations
pressure effects
Crystals
Differential scanning calorimetry
Enantiomers
Engineering Sciences
Equations of state, phase equilibria, and phase transitions
Exact sciences and technology
Fluid Dynamics
Ingredients
Life Sciences
Mechanics
Organic compounds
Pharmaceutical sciences
Phase diagrams
Physics
Solubility
Solubility, segregation, and mixing
phase separation
Structure of solids and liquids
crystallography
Structure of specific crystalline solids
Thermics
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Starting from a mixture of enantiomers in solution, crystallization can generate different types of crystals. In order to determine which type of crystal is obtained in the case of acetyl leucine, an active pharmaceutical ingredient (API), analytical methods have been used to partially elucidate the binary and ternary phase diagrams of the system composed of the two enantiomers and water. The melting temperature phase diagram of this compound has been obtained by using differential scanning calorimetry (DSC) analyzes. The results show that it is characteristic of a conglomerate. This mode of crystallization has also been confirmed by X-ray powder diffraction analysis. Solubility measurements of enantiomerical mixtures in water enabled the determination of the ternary diagram of solubility. The empiric Meyerhoffer double solubility rule has been modified, due to the characterization of interactions between enantiomers.
ISSN:0022-0248
1873-5002
DOI:10.1016/j.jcrysgro.2011.03.023